Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol.
1α-HYDROXYLASE
AMNIOTIC FLUID
CALCITRIOL
CALCIUM
Cyp27b1
FETUS
MINERALIZATION
NEONATE
PARATHYROID HORMONE
PHOSPHORUS
PLACENTA
PLACENTAL CALCIUM TRANSPORT
SKELETON
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
08
2018
revised:
13
11
2018
accepted:
14
11
2018
pubmed:
7
12
2018
medline:
16
7
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
Vitamin D receptor (VDR) null fetuses have normal serum minerals, parathyroid hormone (PTH), skeletal morphology, and mineralization but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. We examined Cyp27b1 null fetal mice, which do not make calcitriol, to determine if loss of calcitriol has the same consequences as loss of VDR. Cyp27b1 null and wild-type (WT) females were mated to Cyp27b1
Substances chimiques
Fgf23 protein, mouse
0
Pregnancy Proteins
0
Receptors, Calcitriol
0
Fibroblast Growth Factor-23
7Q7P4S7RRE
Calcitriol
FXC9231JVH
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
669-680Subventions
Organisme : Janeway Research Foundation
ID : #133413
Pays : International
Organisme : CIHR
ID : #126469
Pays : Canada
Organisme : Discipline of Medicine, Memorial University
Pays : International
Informations de copyright
© 2018 American Society for Bone and Mineral Research.