Mesenchymal stem cells to treat type 1 diabetes.

Animals Diabetes Mellitus, Type 1 / metabolism Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells / metabolism Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells / metabolism
Mesenchymal stem cells Stem cells Type 1 diabetes

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 04 2020
Historique:
received: 05 07 2018
accepted: 26 10 2018
pubmed: 7 12 2018
medline: 4 8 2020
entrez: 4 12 2018
Statut: ppublish

Résumé

What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. This effort exams the history or background of stem cell research in the laboratory and the clinic, types of stem cells, pluripotency or lack thereof based on a variety of pre-clinical investigations attempting endocrine pancreas recovery using stem cell transplantation. The focus is on the use of hematopoietic and mesenchymal stem cells. This review will also examine recent clinical experience following stem cell transplantation in patients with type 1 diabetes.

Identifiants

DOI: 10.1016/j.bbadis.2018.10.033 PMID: 30508575
pubmed: 30508575
pii: S0925-4439(18)30436-8
doi: 10.1016/j.bbadis.2018.10.033
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

165315

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

John S Pixley (JS)

Division of Rheumatology/Immunology, Department of Medicine, Texas Tech University Health Science Center, 3601 4th Street, MS 9410, Lubbock, TX 79430, USA. Electronic address: john.pixley@ttuhsc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches mésenchymateuses › Mesenchymal stem cells to treat type 1 diabetes.
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Mesenchymal stem cells to treat type 1 diabetes.