Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus.

Animals Antiviral Agents / chemical synthesis Furans / chemical synthesis Imidazoles / chemistry Infectious hematopoietic necrosis virus / drug effects Lignans / chemical synthesis Rhabdoviridae Infections / drug therapy Salmon / virology Structure-Activity Relationship Virus Replication / drug effects
Antiviral activity Arctigenin derivatives IHNV

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Feb 2019
Historique:
received: 06 09 2018
revised: 18 11 2018
accepted: 26 11 2018
pubmed: 7 12 2018
medline: 12 2 2019
entrez: 4 12 2018
Statut: ppublish

Résumé

Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease and huge economic losses in the salmonid aquaculture industry. Herein, a series of arctigenin derivatives are synthesized to evaluate their antiviral activity against IHNV. The results indicate that the length of linker and imidazole substituent groups play an important role in decreasing IHNV replication. In this study, the arctigenin-imidazole hybrid derivative 15 with an eight carbon atoms length of the linker reduces IHNV replication with an IC

Identifiants

DOI: 10.1016/j.ejmech.2018.11.064 PMID: 30508667
pubmed: 30508667
pii: S0223-5234(18)31023-7
doi: 10.1016/j.ejmech.2018.11.064
pii:
doi:

Substances chimiques

Antiviral Agents 0
Furans 0
Imidazoles 0
Lignans 0
imidazole 7GBN705NH1
arctigenin U76MR9VS6M

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

183-194

Informations de copyright

Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Auteurs

Yang Hu (Y)

College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China.

Lei Liu (L)

Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang, 315211, China; Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo, Zhejiang, 315211, China.

Boyang Li (B)

College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China.

Yufeng Shen (Y)

College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China.

Gao-Xue Wang (GX)

College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China. Electronic address: wanggaoxue@126.com.

Bin Zhu (B)

College of Animal Science and Technology, Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China. Electronic address: zhubin1227@126.com.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Rhabdoviridae › Novirhabdovirus › Virus de la nécrose hématopoïétique infectieuse › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Lignanes › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Rhabdoviridae › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Salmoniformes › Salmonidae › Saumon › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis of arctigenin derivatives against...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Synthesis of arctigenin derivatives against...