Functional neural mechanisms of sensory phenomena in obsessive-compulsive disorder.
Adult
Brain Mapping
Cerebral Cortex
/ diagnostic imaging
Humans
Interoception
/ physiology
Magnetic Resonance Imaging
Obsessive-Compulsive Disorder
/ diagnostic imaging
Prefrontal Cortex
/ diagnostic imaging
Severity of Illness Index
Somatosensory Cortex
/ diagnostic imaging
Touch Perception
/ physiology
Insula
Neuroimaging
Not-just-right experiences
Sensorimotor
Somatosensory
Urges
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
09
2018
revised:
02
11
2018
accepted:
20
11
2018
pubmed:
6
12
2018
medline:
28
3
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
Sensory phenomena (SP) are aversive or uncomfortable sensations that accompany and/or drive repetitive behaviors in obsessive-compulsive disorder (OCD). Although SP are associated with significant distress and may respond less well to standard treatments than harm-related obsessions, little is known about their underlying neurobiology. The present study used functional magnetic resonance imaging (fMRI) to measure brain functioning related to severity of SP during a "body-focused" videos task designed to elicit activation in sensorimotor brain regions. Regression analysis examined the relationship between severity of SP and activation during task using permutation analysis, cluster-level corrected for multiple comparisons (family-wise error rate p < 0.05). The distribution of SP severity was not significantly different from normal, with both high- and low-severity scores represented in the OCD sample. Severity of SP was not correlated with other clinical symptoms in OCD including general anxiety, depression, or harm avoidance. When viewing body-focused videos, patients with greater severity of SP showed increased activity in the mid-posterior insula, a relationship that remained significant when controlling for other clinical symptoms, medication status, and comorbidities. At uncorrected thresholds, SP severity was also positively related to somatosensory, mid orbitofrontal, and lateral prefrontal cortical activity. These data suggest that SP in OCD are dissociable from other symptoms in the disorder and related to hyperactivation of the insula. Future work examining neural mechanisms of SP across different disorders (tics, trichotillomania) as well as with other imaging modalities will be needed to further understand the neurobiology of these impairing symptoms.
Identifiants
pubmed: 30508745
pii: S0022-3956(18)31076-8
doi: 10.1016/j.jpsychires.2018.11.018
pmc: PMC6347462
mid: NIHMS1515558
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
68-75Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111794
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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