Novel susceptibility variants at the
Acute Disease
Case-Control Studies
Child
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Hispanic or Latino
/ genetics
Humans
Male
Oncogene Proteins, Fusion
/ genetics
Polymorphism, Single Nucleotide
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/ classification
Prognosis
Transcriptional Regulator ERG
/ genetics
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
14 02 2019
14 02 2019
Historique:
received:
10
07
2018
accepted:
13
11
2018
pubmed:
5
12
2018
medline:
19
10
2019
entrez:
5
12
2018
Statut:
ppublish
Résumé
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Characterized by high levels of Native American ancestry, Hispanics are disproportionally affected by this cancer with high incidence and inferior survival. However, the genetic basis for this disparity remains poorly understood because of a paucity of genome-wide investigation of ALL in Hispanics. Performing a genome-wide association study (GWAS) in 940 Hispanic children with ALL and 681 ancestry-matched non-ALL controls, we identified a novel susceptibility locus in the
Identifiants
pubmed: 30510082
pii: S0006-4971(20)42796-X
doi: 10.1182/blood-2018-07-862946
pmc: PMC6376278
doi:
Substances chimiques
ERG protein, human
0
Oncogene Proteins, Fusion
0
Transcriptional Regulator ERG
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
724-729Subventions
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA036401
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180899
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180886
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115279
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by The American Society of Hematology.
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