Effect of continuous positive airway pressure on endothelin-1 in patients with obstructive sleep apnea: a meta-analysis.

Biomarkers / blood Continuous Positive Airway Pressure Endothelin-1 / blood Humans Sleep Apnea, Obstructive / blood
Continuous positive airway pressure Endothelin-1 Meta-analysis Obstructive sleep apnea

Journal

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 31 10 2018
accepted: 26 11 2018
pubmed: 5 12 2018
medline: 26 4 2019
entrez: 5 12 2018
Statut: ppublish

Résumé

Obstructive sleep apnea (OSA) is related to endothelin-1 (ET-1). Continuous positive airway pressure (CPAP) is an effective therapy for OSA. However, the effectiveness of CPAP on ET-1 levels in patients with OSA yielded contradictory results. We conducted a meta-analysis to assess the effect of CPAP on ET-1 levels in OSA. The Embase, and Cochrane Library and PubMed were searched before March, 2018. The overall effects were measured by the standardized mean difference (SMD) with a 95% confidence interval (CI). Ten studies were included and the meta-analysis was conducted using Stata 14.0. 10 studies involving 375 patients were included in the meta-analysis. The result showed that there was a significant reduction in ET-1 levels in OSA patients before and after CPAP therapy (SMD = - 0.74, 95% CI = - 1.30 to - 0.17, z = 2.56, p = 0.01). Further, subgroup analysis demonstrated that Apnea-Hypopnea Index (AHI), CPAP therapy duration, and sample size also affected CPAP therapy. Our meta-analysis indicated that CPAP treatment among OSA patients was significantly was related to a decrease in ET-1 levels. Further prospective long-term studies with a larger number of patients are needed to evaluate and clarify this issue.

Identifiants

DOI: 10.1007/s00405-018-5225-8 PMID: 30511103
pubmed: 30511103
doi: 10.1007/s00405-018-5225-8
pii: 10.1007/s00405-018-5225-8
doi:

Substances chimiques

Biomarkers 0
Endothelin-1 0

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

623-630

Subventions

Organisme : the Chinese National Natural Science Foundation
ID : 81370182

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Auteurs

Guofu Lin (G)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China.

Qingshi Chen (Q)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China.
The Second Affiliated Hospital of Fujian Medical University, Quanzhou, People's Republic of China.

Jiefeng Huang (J)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China.

Lida Chen (L)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China.

Ting Lin (T)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China.

Qichang Lin (Q)

Department of Respiratory Medicine, Fujian Provincial, Fuzhou, People's Republic of China. chang4e@126.com.
Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, Fuzhou, People's Republic of China. chang4e@126.com.
The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, 350005, Fujian, People's Republic of China. chang4e@126.com.
ORCID: 0000-0003-1658-5771

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Effect of continuous positive airway pressure...
questionsmedicales.fr › Thérapeutique › Thérapie respiratoire › Ventilation artificielle › Ventilation à pression positive › Ventilation en pression positive continue › Effect of continuous positive airway pressure...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Endothélines › Endothéline-1 › Effect of continuous positive airway pressure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of continuous positive airway pressure...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Effect of continuous positive airway pressure...