Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.
Blood Platelets
/ metabolism
Coronary Angiography
Coronary Circulation
Female
Gonadal Steroid Hormones
/ blood
Health Status Disparities
Healthcare Disparities
Humans
Male
Myocardial Ischemia
/ blood
Prognosis
Prospective Studies
Registries
Research Design
Risk Factors
Sex Factors
Time Factors
Translational Research, Biomedical
Clinical outcomes
Coronary microvascular dysfunction
Gender
Myocardial blush grade
Platelet function
Sex
Sex steroid hormones
Journal
Journal of cardiovascular translational research
ISSN: 1937-5395
Titre abrégé: J Cardiovasc Transl Res
Pays: United States
ID NLM: 101468585
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
29
08
2018
accepted:
13
11
2018
pubmed:
5
12
2018
medline:
15
9
2020
entrez:
5
12
2018
Statut:
ppublish
Résumé
Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study (Clinicaltrial.gov NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Consecutive patients with IHD undergoing coronary angiography will be recruited: (1) to assess sex and gender differences in angiographic reperfusion indexes; (2) to evaluate the effects of estrogen/androgen on sex-related differences in myocardial ischemia; (3) to investigate the platelet biology differences between men and women with IHD; (4) to verify sex- and gender-driven interplay between response to percutaneous coronary intervention, platelets, sex hormones, and myocardial damage at baseline and its impact on 12-month outcomes. The integration of sex and gender in this translational project on IHD will contribute to the identification of new targets for further innovative clinical interventions.
Identifiants
pubmed: 30511337
doi: 10.1007/s12265-018-9846-5
pii: 10.1007/s12265-018-9846-5
pmc: PMC7010648
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Banques de données
ClinicalTrials.gov
['NCT02737982']
Types de publication
Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-25Investigateurs
Claudio Tiberti
(C)
Federica Panimolle
(F)
Andrea Isidori
(A)
Elisa Giannetta
(E)
Laura Napoleone
(L)
Marta Novo
(M)
Silvia Quattrino
(S)
Simona Ceccarelli
(S)
Eleni Anastasiadou
(E)
Cinzia Marchese
(C)
Enrico Mangieri
(E)
Gaetano Tanzilli
(G)
Nicola Viceconte
(N)
Francesco Barillà
(F)
Carlo Gaudio
(C)
Evaristo Ettorre
(E)
Giulio Francesco Romiti
(GF)
Filippo Toriello
(F)
Eleonora Ruscio
(E)
Tommaso Todisco
(T)
Nicolò Sperduti
(N)
Giuseppe Santangelo
(G)
Giacomo Visioli
(G)
Marco Vano
(M)
Marco Borgi
(M)
Ludovica Maria Antonini
(LM)
Silvia Robuffo
(S)
Claudia Tucci
(C)
Maria Virginia Savoia
(MV)
Agostino Rossoni
(A)
Valeria Spugnardi
(V)
Annarita Vernile
(A)
Mariateresa Santoliquido
(M)
Verdiana Santori
(V)
Giulia Tosti
(G)
Fabrizio Recchia
(F)
Francesco Morricone
(F)
Roberto Scacciavillani
(R)
Alice Lipari
(A)
Andrea Zito
(A)
Floriana Testa
(F)
Giulia Ricci
(G)
Ilaria Vellucci
(I)
Marianna Vincenti
(M)
Silvia Pietropaolo
(S)
Daria Amoroso
(D)
Lucia Stefanini
(L)
Giovanni Talerico
(G)
Pasquale Pignatelli
(P)
Simona Bartimoccia
(S)
Roberto Cangemi
(R)
Salvatore Minisola
(S)
Sebastiano Filetti
(S)
Cristina Nocella
(C)
Louise Pilote
(L)
Tabeth Tsitsi Jiri
(TT)
Muhammad Ahmer Wali
(MA)
Amanpreet Kaur
(A)
Anna Rita Vestri
(AR)
Adriana Servello
(A)
Patrizia Ferroni
(P)
Clara Crescioli
(C)
Cristina Antinozzi
(C)
Francesca Serena Pignataro
(FS)
Tiziana Bellini
(T)
Alessandro Trentini
(A)
Roberto Carnevale
(R)
Carlo Catalano
(C)
Iacopo Carbone
(I)
Nicola Galea
(N)
Giuliano Bertazzoni
(G)
Marianna Suppa
(M)
Antonello Rosa
(A)
Maria Gabriella Scarpellini
(MG)
Alessandro Coppola
(A)
Giulio Illuminati
(G)
Paola Mariani
(P)
Fabrizio Neri
(F)
Paolo Salis
(P)
Antonio Segatori
(A)
Laurent Tellini
(L)
Gianluca Costabile
(G)
Commentaires et corrections
Type : ErratumIn
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