PGC-1β modulates statin-associated myotoxicity in mice.
Animals
Apoptosis
/ drug effects
Atorvastatin
/ metabolism
Female
Hydrogen Peroxide
/ metabolism
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ metabolism
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mitochondria, Muscle
/ drug effects
Muscle, Skeletal
/ drug effects
Myosin Heavy Chains
/ metabolism
Myotoxicity
/ etiology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ genetics
Apoptosis
Atorvastatin
Mitochondrial proliferation
Myopathy
PGC-1β
Reactive oxygen species (ROS)
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
07
2018
accepted:
29
11
2018
pubmed:
5
12
2018
medline:
19
5
2020
entrez:
5
12
2018
Statut:
ppublish
Résumé
Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. Statins are generally well tolerated, but can be associated with potentially life-threatening myopathy of unknown mechanism. We have shown previously that statins impair PGC-1β expression in human and rat skeletal muscle, suggesting that PGC-1β may play a role in statin-induced myopathy. PGC-1β is a transcriptional co-regulator controlling the expression of important genes in mitochondrial biogenesis, antioxidative capacity and energy metabolism. The principle aim of the current study was to investigate the interaction between atorvastatin and PGC-1β in more detail. We therefore treated wild-type mice and mice with selective skeletal muscle knockout of PGC-1β (PGC-1β
Identifiants
pubmed: 30511338
doi: 10.1007/s00204-018-2369-7
pii: 10.1007/s00204-018-2369-7
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, mouse
0
Atorvastatin
A0JWA85V8F
Hydrogen Peroxide
BBX060AN9V
Myosin Heavy Chains
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
487-504Subventions
Organisme : Agence Nationale de la Recherche
ID : 05-PCOD-032
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-10-LABX-0030-INRT
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-10-IDEX-0002-02
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 2010BLAN1108-01
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A_156270
Pays : International