Prognostic significance of expression of myogenin and OCT4 in glioma.

Child Humans Prognosis Brain Neoplasms / diagnosis Myogenin Glioma / diagnosis

Journal

Minerva pediatrics
ISSN: 2724-5780
Titre abrégé: Minerva Pediatr (Torino)
Pays: Italy
ID NLM: 101777303

Informations de publication

Date de publication:
08 2023
Historique:
medline: 21 7 2023
pubmed: 5 12 2018
entrez: 5 12 2018
Statut: ppublish

Résumé

Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease. We used Quantitative Fluorescence PCR (QF-PCR), Enzyme-linked immunosorbent assay (ELISA), and Western-blotting to measure the expression level of myogenin and OCT4 in surgical removed glioma from 41 patients in our hospital. Compared to the healthy children the expression of myogenin and OCT4 was significantly increased in both mRNA and protein level in Glioma tumor cells. In addition, these expressions increased as glioma deterioration. These findings suggesting the expression of myogenin and Oct4 may be useful indicators for predicting the prognosis of children with glioma.

Sections du résumé

BACKGROUND
Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease.
METHODS
We used Quantitative Fluorescence PCR (QF-PCR), Enzyme-linked immunosorbent assay (ELISA), and Western-blotting to measure the expression level of myogenin and OCT4 in surgical removed glioma from 41 patients in our hospital.
RESULTS
Compared to the healthy children the expression of myogenin and OCT4 was significantly increased in both mRNA and protein level in Glioma tumor cells. In addition, these expressions increased as glioma deterioration.
CONCLUSIONS
These findings suggesting the expression of myogenin and Oct4 may be useful indicators for predicting the prognosis of children with glioma.

Identifiants

DOI: 10.23736/S2724-5276.18.05396-3 PMID: 30511560
pubmed: 30511560
pii: S0026-4946.18.05396-3
doi: 10.23736/S2724-5276.18.05396-3
doi:

Substances chimiques

Myogenin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

544-549

Auteurs

Nuo Zheng (N)

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.

Dongli Zhang (D)

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.

Xiaoming Liu (X)

Department of Pediatric Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China - minglx@yeah.net.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Prognostic significance of expression of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic significance of expression of...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic significance of expression of...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Prognostic significance of expression of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteurs de régulation myogènes › Myogénine › Prognostic significance of expression of...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Prognostic significance of expression of...