Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
Animals
Benzamides
/ pharmacology
Cognition
/ drug effects
Disease Models, Animal
Fragile X Syndrome
/ enzymology
Hippocampus
/ drug effects
Histone Deacetylase 6
/ antagonists & inhibitors
Histone Deacetylase Inhibitors
/ pharmacology
Learning
/ drug effects
Memory
/ drug effects
Mice
Protein Processing, Post-Translational
/ drug effects
Quinolines
/ pharmacology
Ames negative
Phenylhydroxamate
acetylated α-tubulin
memory and learning impairments
permeability
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
20 03 2019
20 03 2019
Historique:
pubmed:
5
12
2018
medline:
1
4
2020
entrez:
5
12
2018
Statut:
ppublish
Résumé
Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and ADMET properties, and its ability to improve upon memory performance in a mouse model of FXS, Fmr1
Identifiants
pubmed: 30511829
doi: 10.1021/acschemneuro.8b00600
pmc: PMC6512341
mid: NIHMS1026589
doi:
Substances chimiques
Benzamides
0
Histone Deacetylase Inhibitors
0
Quinolines
0
SW-100
0
Histone Deacetylase 6
EC 3.5.1.98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1679-1695Subventions
Organisme : NINDS NIH HHS
ID : R01 NS079183
Pays : United States
Organisme : CIHR
ID : PJT-153015
Pays : Canada
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