Wnt Signaling in vascular eye diseases.
AMD
Angiogenesis
DR
Development
FEVR
Norrie disease
ROP
Wnt
Journal
Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
24
07
2018
revised:
21
11
2018
accepted:
28
11
2018
pubmed:
5
12
2018
medline:
8
2
2020
entrez:
5
12
2018
Statut:
ppublish
Résumé
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both during the eye development and in vascular eye diseases. Wnt signaling participates in regulating multiple vascular beds in the eye including regression of the hyaloid vessels, and development of structured layers of vasculature in the retina. Loss-of-function mutations in Wnt signaling components cause rare genetic eye diseases in humans such as Norrie disease, and familial exudative vitreoretinopathy (FEVR) with defective ocular vasculature. On the other hand, experimental studies in more prevalent vascular eye diseases, such as wet age-related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), and corneal neovascularization, suggest that aberrantly increased Wnt signaling is one of the causations for pathological ocular neovascularization, indicating the potential of modulating Wnt signaling to ameliorate pathological angiogenesis in eye diseases. This review recapitulates the key roles of the Wnt signaling pathway during ocular vascular development and in vascular eye diseases, and pharmaceutical approaches targeting the Wnt signaling as potential treatment options.
Identifiants
pubmed: 30513356
pii: S1350-9462(18)30046-6
doi: 10.1016/j.preteyeres.2018.11.008
pmc: PMC6545170
mid: NIHMS1516402
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-133Subventions
Organisme : NEI NIH HHS
ID : R01 EY024963
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028100
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Nature. 2000 Jul 6;406(6791):86-90
pubmed: 10894547
PLoS One. 2017 Jun 2;12(6):e0178753
pubmed: 28575130
Mol Cell Biol. 2015 Jun 1;35(11):1979-91
pubmed: 25802278
Nat Genet. 2000 Mar;24(3):245-50
pubmed: 10700176
J Cell Biol. 2008 Nov 3;183(3):409-17
pubmed: 18955553
Curr Neuropharmacol. 2008 Jun;6(2):164-78
pubmed: 19305795
PLoS One. 2010 Jul 20;5(7):e11676
pubmed: 20652025
Angiogenesis. 2007;10(2):133-40
pubmed: 17332988
Arch Ophthalmol. 2002 Mar;120(3):338-46
pubmed: 11879138
Mol Vis. 2015 Jun 12;21:665-72
pubmed: 26120271
Hum Mol Genet. 1999 Oct;8(11):2031-5
pubmed: 10484772
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2813-26
pubmed: 20484600
Anat Embryol (Berl). 1999 Oct;200(4):403-11
pubmed: 10460477
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6906-11
pubmed: 20351293
Br J Ophthalmol. 2011 Apr;95(4):574-9
pubmed: 21097938
Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7386-94
pubmed: 24130179
Invest Ophthalmol Vis Sci. 1995 Jun;36(7):1201-14
pubmed: 7775098
Am J Pathol. 2014 Oct;184(10):2709-20
pubmed: 25108226
CNS Neurosci Ther. 2017 Dec;23(12):947-960
pubmed: 28961379
Semin Cell Dev Biol. 2008 Apr;19(2):125-33
pubmed: 17920963
Int J Ophthalmol. 2015 Feb 18;8(1):182-93
pubmed: 25709930
Dev Biol. 2017 Aug 15;428(2):273-282
pubmed: 28526587
PLoS One. 2014 Jul 16;9(7):e102559
pubmed: 25029272
Curr Drug Targets. 2008 Jul;9(7):558-64
pubmed: 18673241
Mol Cell Biol. 2011 Jul;31(14):3038-51
pubmed: 21576363
Nat Genet. 1993 Dec;5(4):376-80
pubmed: 8298646
Elife. 2015 Jul 09;4:
pubmed: 26158506
Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8614-25
pubmed: 25414188
J Neurosci. 2005 Feb 16;25(7):1701-10
pubmed: 15716406
Exp Eye Res. 2018 Sep;174:107-112
pubmed: 29864439
Gene Expr Patterns. 2011 Jan-Feb;11(1-2):151-5
pubmed: 21055480
Nature. 2011 May 29;474(7352):511-5
pubmed: 21623369
FASEB J. 2001 Sep;15(11):2013-5
pubmed: 11511521
Am J Hum Genet. 2004 Apr;74(4):721-30
pubmed: 15024691
Genes Dev. 2008 Mar 15;22(6):746-55
pubmed: 18347094
J Exp Med. 2017 Jun 5;214(6):1753-1767
pubmed: 28465464
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(2):121-33
pubmed: 6906151
Cell. 1992 Jun 26;69(7):1073-87
pubmed: 1617723
Rev Endocr Metab Disord. 2015 Jun;16(2):141-8
pubmed: 26048454
J Neurosci. 2012 Jan 25;32(4):1197-206
pubmed: 22279205
Int J Dev Biol. 2004;48(8-9):1045-58
pubmed: 15558494
Diabetes. 2010 Jul;59(7):1809-16
pubmed: 20299474
J Cell Biol. 2003 Jun 23;161(6):1163-77
pubmed: 12810700
J Biol Chem. 2004 Jun 4;279(23):24659-65
pubmed: 15067007
Nat Genet. 1992 Jun;1(3):199-203
pubmed: 1303235
Dev Cell. 2009 Jul;17(1):9-26
pubmed: 19619488
Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):141-54
pubmed: 23211829
Circulation. 2017 Jul 11;136(2):180-195
pubmed: 28356444
Cell. 1982 Nov;31(1):99-109
pubmed: 6297757
Biochem Biophys Res Commun. 1999 Sep 24;263(2):384-8
pubmed: 10491302
J Neurosci. 2002 Jun 1;22(11):4286-92
pubmed: 12040033
FASEB J. 2017 Nov;31(11):4665-4681
pubmed: 28739642
Mol Med Rep. 2017 Sep;16(3):3351-3356
pubmed: 28713924
Invest Ophthalmol Vis Sci. 2014 May 20;55(6):3820-32
pubmed: 24845641
Neuropharmacology. 2015 Apr;91:1-12
pubmed: 25486619
Nat Genet. 2011 Sep 04;43(10):964-968
pubmed: 21892161
Arch Ophthalmol. 1997 May;115(5):651-5
pubmed: 9152134
Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4371-9
pubmed: 19875668
Prog Retin Eye Res. 2009 Mar;28(2):87-116
pubmed: 19071227
PLoS One. 2012;7(1):e30203
pubmed: 22272305
Am J Hum Genet. 2003 Mar;72(3):763-71
pubmed: 12579474
J Hum Genet. 2001;46(4):178-81
pubmed: 11322656
Prog Retin Eye Res. 2007 Jul;26(4):437-51
pubmed: 17512238
Diabetologia. 2018 Nov;61(11):2433-2446
pubmed: 30019207
Nat Rev Neurol. 2013 Jan;9(1):44-53
pubmed: 23165340
J Invest Dermatol. 2014 Jun;134(6):1725-1734
pubmed: 24463424
J Cell Physiol. 2002 Aug;192(2):182-7
pubmed: 12115724
Nature. 1999 Apr 1;398(6726):431-6
pubmed: 10201374
Development. 2014 Apr;141(8):1757-66
pubmed: 24715464
Angiogenesis. 2008;11(1):63-9
pubmed: 18253847
Prog Retin Eye Res. 2009 Nov;28(6):452-82
pubmed: 19563909
Prog Retin Eye Res. 2008 Jul;27(4):331-71
pubmed: 18653375
J Cell Sci. 2014 Nov 15;127(Pt 22):4857-69
pubmed: 25271056
Dev Cell. 2014 Oct 27;31(2):248-56
pubmed: 25373781
Prog Retin Eye Res. 2010 Mar;29(2):135-43
pubmed: 20006728
Nat Med. 2017 Apr;23(4):450-460
pubmed: 28288111
Prog Retin Eye Res. 2006 Nov;25(6):563-90
pubmed: 17079182
Exp Diabetes Res. 2012;2012:518426
pubmed: 21754923
PPAR Res. 2015;2015:595426
pubmed: 25705219
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7
pubmed: 25901317
J Clin Invest. 2011 May;121(5):1882-93
pubmed: 21540552
Front Cell Dev Biol. 2016 Nov 30;4:138
pubmed: 27965955
N Engl J Med. 2014 Jan 30;370(5):412-20
pubmed: 24382002
Oncotarget. 2018 Sep 4;9(69):33244
pubmed: 30237865
Nat Med. 2011 Jun;17(6):684-91
pubmed: 21602802
Retina. 2007 Feb;27(2):243-6
pubmed: 17290208
J Immunol. 2004 Jan 15;172(2):1099-108
pubmed: 14707084
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10918-10923
pubmed: 28973878
Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4158-68
pubmed: 21447684
Invest Ophthalmol Vis Sci. 2014 Nov 06;55(12):8044-53
pubmed: 25377223
Data Brief. 2017 Oct 06;15:491-495
pubmed: 29062875
Nat Protoc. 2009;4(11):1565-73
pubmed: 19816419
Cell Cycle. 2009 Dec 15;8(24):4032-9
pubmed: 19923896
Am J Pathol. 1999 Dec;155(6):1795-801
pubmed: 10595907
Sci Rep. 2017 Apr 28;7(1):1263
pubmed: 28455497
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6900-5
pubmed: 20351274
J Biol Chem. 2005 May 20;280(20):19883-7
pubmed: 15778503
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5030-5042
pubmed: 28979999
Cell. 2009 Oct 16;139(2):285-98
pubmed: 19837032
Prog Retin Eye Res. 2009 Mar;28(2):117-44
pubmed: 19114125
Invest Ophthalmol Vis Sci. 2014 Jul 17;55(9):5522-30
pubmed: 25034605
Circ Res. 2010 Oct 15;107(8):943-52
pubmed: 20947863
Cell. 2012 Dec 7;151(6):1332-44
pubmed: 23217714
Invest Ophthalmol Vis Sci. 1996 Nov;37(12):2367-75
pubmed: 8933753
Protein Cell. 2010 Oct;1(10):898-906
pubmed: 21204016
Cell. 1990 Sep 21;62(6):1073-85
pubmed: 2205396
Science. 1997 Mar 21;275(5307):1787-90
pubmed: 9065402
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12163-8
pubmed: 26374840
Am J Hum Genet. 2018 Jan 4;102(1):27-43
pubmed: 29276006
Microvasc Res. 2018 Sep;119:29-37
pubmed: 29630973
J Clin Invest. 2008 Feb;118(2):526-33
pubmed: 18219389
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22
pubmed: 22753465
IUBMB Life. 2005 Jun;57(6):381-8
pubmed: 16012046
Mol Vis. 2005 Jul 14;11:501-8
pubmed: 16052165
Dev Cell. 2015 Jan 12;32(1):82-96
pubmed: 25584796
Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3500-10
pubmed: 12407162
Neuron. 2005 Apr 7;46(1):23-36
pubmed: 15820691
Nat Med. 2016 Apr;22(4):439-45
pubmed: 26974308
Prog Retin Eye Res. 2010 May;29(3):208-48
pubmed: 20100589
Mol Vis. 2009;15:26-37
pubmed: 19137075
J Biol Chem. 2005 May 6;280(18):18525-35
pubmed: 15753085
Nat Genet. 1993 Oct;5(2):180-3
pubmed: 8252044
Prog Retin Eye Res. 2004 Sep;23(5):561-77
pubmed: 15302351
Am J Hum Genet. 2010 Feb 12;86(2):248-53
pubmed: 20159112
J Neurosci. 2010 Jan 6;30(1):183-93
pubmed: 20053900
J Biol Chem. 2007 Jan 5;282(1):782-91
pubmed: 17098737
Dev Genes Evol. 2015 Apr;225(2):121-8
pubmed: 25689933
Science. 2014 Oct 3;346(6205):1248012
pubmed: 25278615
Am J Pathol. 2013 Feb;182(2):586-96
pubmed: 23195430
Eye (Lond). 2014 Apr;28(4):402-9
pubmed: 24406409
N Engl J Med. 2006 Jul 20;355(3):241-50
pubmed: 16855264
Genes Chromosomes Cancer. 2001 Mar;30(3):316-21
pubmed: 11170292
Hum Mol Genet. 2008 Jun 1;17(11):1605-12
pubmed: 18263894
Kidney Int. 2017 Mar;91(3):642-657
pubmed: 27914705
BMC Dev Biol. 2002 Jul 02;2:8
pubmed: 12095419
Cell. 2014 Oct 23;159(3):584-96
pubmed: 25417109
Biol Reprod. 2005 Dec;73(6):1135-46
pubmed: 16093361
Mol Cell Biochem. 2013 Jul;379(1-2):295-301
pubmed: 23666756
Elife. 2016 Feb 04;5:e07727
pubmed: 26845523
Am J Hum Genet. 2013 Apr 4;92(4):590-7
pubmed: 23499310
Prog Retin Eye Res. 2006 May;25(3):277-95
pubmed: 16515881
Exp Eye Res. 2017 Nov;164:129-138
pubmed: 28823941
Cell Stem Cell. 2008 Nov 6;3(5):508-18
pubmed: 18983966
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11405-10
pubmed: 16849433
Cell. 2009 Oct 16;139(2):299-311
pubmed: 19837033
Exp Cell Res. 2003 Dec 10;291(2):415-25
pubmed: 14644163
Annu Rev Vis Sci. 2018 Sep 15;4:101-122
pubmed: 30222533
Br J Ophthalmol. 1993 Mar;77(3):168-70
pubmed: 8457509
Nat Commun. 2017 Jul 04;8:16050
pubmed: 28675177
Dev Cell. 2010 Jun 15;18(6):938-49
pubmed: 20627076
Cancer Treat Rev. 2018 Jan;62:50-60
pubmed: 29169144
N Engl J Med. 2012 Dec 27;367(26):2515-26
pubmed: 23268666
Am J Hum Genet. 2005 Nov;77(5):741-53
pubmed: 16252235
Nat Med. 2006 Apr;12(4):395-7
pubmed: 16565724
Am J Hum Genet. 2004 May;74(5):1043-50
pubmed: 15042511
Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2874-2883
pubmed: 28586911
Prog Retin Eye Res. 2018 May;64:131-156
pubmed: 29175509
Invest Ophthalmol Vis Sci. 2011 Jul 01;52(7):4734-41
pubmed: 21357396
Nat Med. 2004 Jan;10(1):55-63
pubmed: 14702635
Vision Res. 2017 Oct;139:47-58
pubmed: 28545982
Am J Pathol. 2009 Dec;175(6):2676-85
pubmed: 19893025
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2369-2380
pubmed: 27758766
Prog Retin Eye Res. 2018 Jan;62:58-76
pubmed: 29081352
Prog Retin Eye Res. 2008 Jul;27(4):372-90
pubmed: 18621565
N Engl J Med. 2012 Mar 29;366(13):1227-39
pubmed: 22455417
Prog Retin Eye Res. 2003 Jan;22(1):1-29
pubmed: 12597922
Front Immunol. 2016 Sep 22;7:378
pubmed: 27713747
Dev Biol. 2007 May 15;305(2):421-9
pubmed: 17425953
Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):
pubmed: 23209129
Angiogenesis. 2007;10(2):77-88
pubmed: 17322966
Invest Ophthalmol Vis Sci. 2014 May 13;55(7):4568-76
pubmed: 24825105
Development. 2018 Jun 14;145(12):
pubmed: 29777010
Nat Rev Cancer. 2013 Jan;13(1):11-26
pubmed: 23258168
Am J Hum Genet. 2002 Jan;70(1):11-9
pubmed: 11741193
Br J Ophthalmol. 2000 Nov;84(11):1269-74
pubmed: 11049953
Science. 2008 Nov 21;322(5905):1247-50
pubmed: 19023080
Science. 1991 Aug 9;253(5020):665-9
pubmed: 1651563
Nature. 2018 Aug;560(7719):484-488
pubmed: 30111842
Cancer Res. 2001 Aug 15;61(16):6050-4
pubmed: 11507052
Diabetes. 2013 Dec;62(12):4228-38
pubmed: 23884893
Nat Med. 2013 Feb;19(2):179-92
pubmed: 23389618
Curr Eye Res. 2010 Apr;35(4):274-80
pubmed: 20373893
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10705-9
pubmed: 8248162
Prog Retin Eye Res. 2013 Nov;37:68-89
pubmed: 23933169
Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2450-7
pubmed: 9804153
Int J Ophthalmol. 2017 Dec 18;10(12):1791-1797
pubmed: 29259894
Invest Ophthalmol Vis Sci. 1994 Jan;35(1):101-11
pubmed: 7507904
J Med Genet. 2013 May;50(5):345-8
pubmed: 23434763
FASEB J. 2003 May;17(8):896-8
pubmed: 12670875
Nat Genet. 1998 Aug;19(4):379-83
pubmed: 9697701
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9434-9
pubmed: 17517621
Am J Hum Genet. 2004 Mar;74(3):558-63
pubmed: 14872406
Science. 2018 Aug 17;361(6403):
pubmed: 30026314
Nature. 1999 Apr 1;398(6726):422-6
pubmed: 10201372
Nature. 2005 Sep 15;437(7057):417-21
pubmed: 16163358
Hum Genet. 1985;71(3):211-4
pubmed: 2998969
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5065-5075
pubmed: 28980001
Development. 1996 Nov;122(11):3343-53
pubmed: 8951051
Am J Hum Genet. 2010 Feb 12;86(2):240-7
pubmed: 20159111
Prog Retin Eye Res. 2014 Nov;43:92-107
pubmed: 25128741
PLoS One. 2014 Oct 01;9(10):e108454
pubmed: 25271989
Trends Mol Med. 2010 Sep;16(9):417-25
pubmed: 20688566
Circulation. 2011 Oct 25;124(17):1871-81
pubmed: 21969016
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2240-2251
pubmed: 29715368
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):641-6
pubmed: 19129494
PLoS One. 2015 Dec 02;10(12):e0143650
pubmed: 26630461
Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3943-52
pubmed: 19324842
Carcinogenesis. 2010 May;31(5):946-52
pubmed: 20176656
Nat Genet. 2006 Mar;38(3):320-3
pubmed: 16415884
Mol Cell Biol. 2016 Sep 26;36(20):2645-54
pubmed: 27528615
PLoS One. 2014 Oct 08;9(10):e108859
pubmed: 25296038
Exp Cell Res. 2013 May 15;319(9):1317-23
pubmed: 23291327
Lancet. 2013 Oct 26;382(9902):1445-57
pubmed: 23782686
Cell. 2001 Nov 16;107(4):513-23
pubmed: 11719191
Cancer Res. 2017 Dec 1;77(23):6562-6575
pubmed: 29021137
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10457-61
pubmed: 7479819
Nature. 2002 Jun 6;417(6889):664-7
pubmed: 12050670
PLoS Biol. 2006 Apr;4(4):e115
pubmed: 16602827
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6315-20
pubmed: 19325125
Cell. 2004 Mar 19;116(6):883-95
pubmed: 15035989
J Cell Biol. 2000 Feb 7;148(3):567-78
pubmed: 10662781
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1329-35
pubmed: 18952918
Neuron. 2017 Aug 30;95(5):1221-1225
pubmed: 28858622
Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):905-9
pubmed: 7846076
J Cell Biol. 2002 Apr 15;157(2):303-14
pubmed: 11956231
Cell. 2007 Jun 29;129(7):1401-14
pubmed: 17604727
Am J Ophthalmol. 1969 Oct;68(4):578-94
pubmed: 5394449
PLoS Biol. 2012;10(3):e1001286
pubmed: 22448144
Ophthalmic Genet. 2010 Mar;31(1):37-43
pubmed: 20141357
Acta Histochem. 2013 Jun;115(5):447-51
pubmed: 23206555
Eur J Ophthalmol. 2002 Nov-Dec;12(6):467-72
pubmed: 12510715
Nature. 2010 Apr 15;464(7291):1043-7
pubmed: 20393562
Development. 2018 Nov 2;145(21):
pubmed: 30254141
Prog Retin Eye Res. 2018 Jan;62:77-119
pubmed: 28958885
Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2384-90
pubmed: 15223821
Prog Retin Eye Res. 2017 Jan;56:32-57
pubmed: 27671171
Cell Rep. 2018 Oct 9;25(2):339-349.e9
pubmed: 30304675
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):906-16
pubmed: 18978344
Cancer Res. 2002 Oct 15;62(20):5651-6
pubmed: 12384519
Am Rev Respir Dis. 1989 Oct;140(4):1097-103
pubmed: 2478056
Curr Diab Rep. 2011 Aug;11(4):253-64
pubmed: 21611764
Exp Eye Res. 2016 Apr;145:317-326
pubmed: 26706283
Cell Mol Neurobiol. 2011 Jan;31(1):163-73
pubmed: 21061158
Bone. 2017 Sep;102:26-30
pubmed: 28341377
Mol Vis. 1999 Nov 03;5:27
pubmed: 10562651
Cancer Res. 1998 Mar 1;58(5):896-9
pubmed: 9500446
Diabetes. 2012 Nov;61(11):2948-57
pubmed: 22891217
Prog Retin Eye Res. 2003 Nov;22(6):721-48
pubmed: 14575722
J Transl Med. 2015 Oct 17;13:330
pubmed: 26476672
Nature. 1999 Feb 25;397(6721):707-10
pubmed: 10067895
Development. 2015 Oct 1;142(19):3383-93
pubmed: 26443636
Am J Med Genet A. 2014 Dec;164A(12):2996-3002
pubmed: 25250762
Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):682-8
pubmed: 16970763
Annu Rev Cell Dev Biol. 2004;20:781-810
pubmed: 15473860
Nature. 2003 Apr 24;422(6934):905-9
pubmed: 12712206
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8847-51
pubmed: 9671767
Prog Retin Eye Res. 2017 Sep;60:181-200
pubmed: 28411123
Nature. 2014 Jul 17;511(7509):358-61
pubmed: 25030175
J Exp Med. 2016 Jun 27;213(7):1175-83
pubmed: 27325890
Cell. 2009 Jun 12;137(6):1124-35
pubmed: 19524514
Prog Retin Eye Res. 2015 Nov;49:67-81
pubmed: 26113211
Am J Hum Genet. 2015 Apr 2;96(4):612-22
pubmed: 25817016
Prog Retin Eye Res. 2018 Mar;63:1-19
pubmed: 29129724
Prog Retin Eye Res. 2012 May;31(3):243-57
pubmed: 22387751
Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867
pubmed: 29394407
Invest Ophthalmol Vis Sci. 2013 Jan 09;54(1):222-9
pubmed: 23188723
Nature. 2006 Oct 26;443(7114):993-7
pubmed: 17051153
Circ Res. 2006 May 26;98(10):1331-9
pubmed: 16601226
Am J Hum Genet. 2015 Oct 1;97(4):621-6
pubmed: 26387593
Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H738-49
pubmed: 27473938
Ann Med. 2006;38(7):450-71
pubmed: 17101537
Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5088-97
pubmed: 17065530
N Engl J Med. 2005 Aug 25;353(8):782-92
pubmed: 16120858
Genomics. 1995 May 20;27(2):341-4
pubmed: 7558002
Cell Rep. 2017 Jun 27;19(13):2809-2822
pubmed: 28658627
Nature. 1997 Apr 17;386(6626):671-4
pubmed: 9109485
Oncogene. 2006 Dec 4;25(57):7482-91
pubmed: 17143292
Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8267-77
pubmed: 25414194
Nat Genet. 2000 Oct;26(2):146-7
pubmed: 11017067
Sci Rep. 2017 Feb 17;7:42846
pubmed: 28211523
Oncogene. 2006 Dec 4;25(57):7469-81
pubmed: 17143291
Fetal Pediatr Pathol. 2017 Jun;36(3):240-245
pubmed: 28394646
Cell. 1997 Jul 11;90(1):181-92
pubmed: 9230313
N Engl J Med. 2002 May 16;346(20):1513-21
pubmed: 12015390
Dev Cell. 2010 Apr 20;18(4):579-91
pubmed: 20412773
Dev Biol. 2014 Jul 15;391(2):241-50
pubmed: 24809797
Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5733-41
pubmed: 18055826
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):855-64
pubmed: 25657312
Curr Opin Pediatr. 2011 Apr;23(2):173-8
pubmed: 21150442
Growth Factors. 2007 Feb;25(1):25-32
pubmed: 17454147
Int J Mol Med. 2017 Sep;40(3):587-606
pubmed: 28731148
J Cell Biol. 2009 Jan 12;184(1):83-99
pubmed: 19139264
Am J Pathol. 2008 Jan;172(1):37-49
pubmed: 18156211
Exp Eye Res. 2009 Oct;89(4):462-8
pubmed: 19422823
Nat Cell Biol. 2011 Aug 14;13(9):1070-5
pubmed: 21841791
Front Biosci. 2006 Sep 01;11:2442-64
pubmed: 16720326
Curr Opin Genet Dev. 2009 Oct;19(5):476-83
pubmed: 19864126
Dev Dyn. 2010 Jan;239(1):327-37
pubmed: 19918918
Nat Genet. 1999 Aug;22(4):361-5
pubmed: 10431240
Prog Retin Eye Res. 2008 Nov;27(6):608-21
pubmed: 18929676
Hum Mutat. 2005 Aug;26(2):104-12
pubmed: 15981244
Nature. 2005 Dec 15;438(7070):960-6
pubmed: 16355161
PLoS One. 2012;7(6):e39336
pubmed: 22745736
Nat Genet. 2002 Oct;32(2):326-30
pubmed: 12172548
J Biomed Sci. 2010 Aug 25;17:69
pubmed: 20738858
Prog Retin Eye Res. 2007 Jan;26(1):1-37
pubmed: 17074526
J Ocul Pharmacol Ther. 2013 Sep;29(7):619-26
pubmed: 23545016
J Exp Med. 2012 Aug 27;209(9):1611-27
pubmed: 22908324
Nat Genet. 1992 Jun;1(3):204-8
pubmed: 1303236
Clin Exp Ophthalmol. 2009 Dec;37(9):884-90
pubmed: 20092598
EMBO J. 2014 Jan 13;33(2):146-56
pubmed: 24413017
J R Soc Interface. 2012 Sep 7;9(74):2351-64
pubmed: 22438490
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1398-407
pubmed: 27018842
Clin Genet. 1976 Mar;9(3):324-32
pubmed: 1261071
Cell. 2015 Nov 19;163(5):1225-1236
pubmed: 26590424
Am J Hum Genet. 2004 Nov;75(5):878-84
pubmed: 15346351
Cell Metab. 2013 May 7;17(5):745-55
pubmed: 23623748
Arch Ophthalmol. 1961 Nov;66:614-8
pubmed: 13861187
Development. 1989 Mar;105(3):473-85
pubmed: 2612361
Cell Rep. 2016 Sep 27;17(1):165-178
pubmed: 27681429
PLoS One. 2010 Jul 29;5(7):e11863
pubmed: 20686684
J Neurosci. 2010 Apr 28;30(17):5998-6010
pubmed: 20427659
Am J Pathol. 2016 Oct;186(10):2588-600
pubmed: 27524797
Eye Brain. 2016 Aug 09;8:141-146
pubmed: 28539809
J Biol Chem. 2007 Nov 23;282(47):34420-8
pubmed: 17890782
Am J Hum Genet. 2016 Mar 3;98(3):553-561
pubmed: 26924530
FEBS Lett. 2015 Apr 28;589(10):1143-1149
pubmed: 25796186
J Cell Biol. 2003 May 12;161(3):653-60
pubmed: 12743111
Cold Spring Harb Perspect Med. 2013 Jan 01;3(1):a006569
pubmed: 23085847
J Cell Sci. 2003 Jul 1;116(Pt 13):2627-34
pubmed: 12775774
Nat Cell Biol. 2001 Jul;3(7):683-6
pubmed: 11433302
Eur J Pharmacol. 2008 May 13;585(2-3):338-45
pubmed: 18417121
Invest Ophthalmol Vis Sci. 2014 Jul 15;:
pubmed: 25028361
J Cell Biol. 2003 Sep 15;162(6):1111-22
pubmed: 12975353
Dev Dyn. 2003 Jul;227(3):323-34
pubmed: 12815618
Prog Retin Eye Res. 2013 Jan;32:102-80
pubmed: 22982179
Nature. 2007 Feb 15;445(7129):776-80
pubmed: 17259973
Dev Dyn. 2006 Nov;235(11):3110-20
pubmed: 17013885
Cancer Res. 1998 Apr 1;58(7):1344-7
pubmed: 9537226
Glia. 2010 Aug;58(10):1177-85
pubmed: 20544853
Diabetes. 2016 Dec;65(12):3730-3743
pubmed: 27543085
Invest Ophthalmol Vis Sci. 2011 Aug 16;52(9):6452-61
pubmed: 21743011
Ophthalmic Paediatr Genet. 1993 Mar;14(1):1-3
pubmed: 8345950
Dev Dyn. 2013 Jun;242(6):738-51
pubmed: 23444323
Retina. 2017 Dec;37(12):2208-2225
pubmed: 28541957
Science. 1998 Sep 4;281(5382):1509-12
pubmed: 9727977
Curr Opin Cell Biol. 2018 Apr;51:110-116
pubmed: 29289896
Nature. 1988 Apr 28;332(6167):834-7
pubmed: 3282180
Cancer Res. 2003 Apr 15;63(8):1906-13
pubmed: 12702582
Cancer Res. 2001 Dec 1;61(23):8401-4
pubmed: 11731417
Clin Genet. 1998 Oct;54(4):315-20
pubmed: 9831343
J Biol Chem. 2006 Dec 15;281(50):38276-84
pubmed: 17052975
Ophthalmology. 2015 Sep;122(9):1917-23
pubmed: 26119001
Science. 2007 Mar 2;315(5816):1278-82
pubmed: 17332414
Cancer Lett. 2003 Jun 30;196(1):1-12
pubmed: 12860282
Mol Cell Biol. 2008 Apr;28(8):2732-44
pubmed: 18268006
Ophthalmology. 2015 Nov;122(11):2270-7
pubmed: 26299697
Hum Mol Genet. 1997 Mar;6(3):465-72
pubmed: 9147651
Diabetes. 2013 Jan;62(1):261-72
pubmed: 23043158
Lancet. 2010 Jul 10;376(9735):124-36
pubmed: 20580421
Science. 1991 Aug 9;253(5020):661-5
pubmed: 1651562
Hum Mol Genet. 2016 Apr 15;25(8):1637-47
pubmed: 26908610
Cell. 2017 Jun 1;169(6):985-999
pubmed: 28575679
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 22661590
Nat Cell Biol. 2008 Mar;10(3):329-37
pubmed: 18264090
Dev Cell. 2005 Sep;9(3):389-402
pubmed: 16139227
Prog Retin Eye Res. 2010 Nov;29(6):500-19
pubmed: 20488255
Prog Retin Eye Res. 2008 Nov;27(6):579-95
pubmed: 18775790
Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3372-82
pubmed: 16123442
Hepatology. 2008 Mar;47(3):1018-31
pubmed: 18302287
Int J Hematol. 2017 Jun;105(6):748-757
pubmed: 28299632
J Mol Neurosci. 2017 Aug;62(3-4):368-379
pubmed: 28689265
Circulation. 2017 Jun 20;135(25):2505-2523
pubmed: 28381471
Graefes Arch Clin Exp Ophthalmol. 1992;230(3):248-51
pubmed: 1350768