A simple problem formulation framework to create the right solution to the right problem.

Chemical Pesticide Problem formulation Risk assessment Solution

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 17 05 2018
revised: 28 11 2018
accepted: 29 11 2018
pubmed: 5 12 2018
medline: 25 1 2019
entrez: 5 12 2018
Statut: ppublish

Résumé

A systematic approach to formulate consistent, technically robust and scientifically tractable problems will facilitate achieving innovative and effective solutions in risk evaluation. The fundamentals of problem formulation have been adapted from environmental and human health risk assessments. A structured problem formulation enables focus on describing and evaluating the specifics of the problem to be solved, instead of immediately creating solutions. First the problem should be framed to provide clarity and gain agreement on the problem to be addressed, resulting in a specific problem statement. Second the problem is explored in order to transform it into an operational state through questions to answer, hypotheses to test, and represented by a conceptual model. Finally the approach to testing hypotheses is mapped and the analysis plan is developed to address the problem statement. This simple adaptable framework can be applied to any circumstance to resolve a specific problem and describe a path to resolution.

Identifiants

pubmed: 30513358
pii: S0273-2300(18)30307-6
doi: 10.1016/j.yrtph.2018.11.015
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

187-193

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Alaina Sauve-Ciencewicki (A)

Syngenta Crop Protection, Research Triangle Park, NC, 27709, USA.

Kathryn P Davis (KP)

Syngenta Crop Protection, Research Triangle Park, NC, 27709, USA.

Justin McDonald (J)

Syngenta Crop Protection, Research Triangle Park, NC, 27709, USA.

Tharacad Ramanarayanan (T)

Syngenta Crop Protection, Greensboro, NC, USA.

Alan Raybould (A)

Syngenta Crop Protection, Basel, Switzerland.

Douglas C Wolf (DC)

Syngenta Crop Protection, Research Triangle Park, NC, 27709, USA. Electronic address: doug.wolf@syngenta.com.

Ted Valenti (T)

Syngenta Crop Protection, Greensboro, NC, USA.

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Classifications MeSH