Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study.
Aged
Antimetabolites, Antineoplastic
/ therapeutic use
Biomarkers
Combined Modality Therapy
/ methods
Cytokine-Induced Killer Cells
/ immunology
Dendritic Cells
/ immunology
Drug Combinations
Female
Humans
Immunotherapy
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Oxonic Acid
/ therapeutic use
Prospective Studies
Retreatment
Stomach Neoplasms
/ diagnosis
Tegafur
/ therapeutic use
Treatment Outcome
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
23
07
2018
revised:
20
09
2018
accepted:
28
11
2018
pubmed:
6
12
2018
medline:
9
4
2020
entrez:
6
12
2018
Statut:
ppublish
Résumé
We have assessed the combination of DC-CIK with S-1 plus cisplatin chemotherapy in advanced gastric cancer (AGC) and the role of mutational analysis of circulating tumor DNA (ctDNA) and T-cell receptor (TCR) repertoire in predicting clinical outcomes. Consecutive patients ( The DC-CIK infusions were well tolerated with no serious adverse events. The disease control rates (CR DC-CIK combined with S-1 plus cisplatin provided a favorable PFS and OS in patients with AGC and the combination therapy was safe with tolerable toxicities. Clinical efficacy correlated with decreases in ctDNA mutational profiles and restored TCR repertoire.
Identifiants
pubmed: 30514775
pii: 1078-0432.CCR-18-2360
doi: 10.1158/1078-0432.CCR-18-2360
doi:
Substances chimiques
Antimetabolites, Antineoplastic
0
Biomarkers
0
Drug Combinations
0
S 1 (combination)
150863-82-4
Tegafur
1548R74NSZ
Oxonic Acid
5VT6420TIG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1494-1504Informations de copyright
©2018 American Association for Cancer Research.