Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair.
Adolescent
Adult
Animals
Biocompatible Materials
Cartilage Diseases
/ drug therapy
Cartilage, Articular
/ drug effects
Female
Gene Transfer Techniques
Genetic Therapy
/ methods
Genetic Vectors
Humans
Hydrogels
Male
Models, Animal
Osteoarthritis
/ therapy
Rabbits
Regenerative Medicine
/ methods
Tissue Engineering
/ methods
Tissue Scaffolds
Journal
Nature reviews. Rheumatology
ISSN: 1759-4804
Titre abrégé: Nat Rev Rheumatol
Pays: United States
ID NLM: 101500080
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
6
12
2018
medline:
19
2
2020
entrez:
6
12
2018
Statut:
ppublish
Résumé
Articular cartilage defects are prevalent and are potentially involved in the initiation of osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents a substantial challenge. Molecular treatments that require the delivery of therapeutic gene vectors are often less effective that specific, targeted approaches, and the scientific evidence for acellular biomaterial-assisted procedures is limited. Controlled delivery of gene vectors using biocompatible materials is emerging as a novel strategy for the sustained and tuneable release of gene therapies in a spatiotemporally precise manner, thereby reducing intra-articular vector spread and possible loss of the therapeutic gene product. Controlled, biomaterial-guided delivery of gene vectors could be used to enhance intrinsic mechanisms of cartilage repair while affording protection against potentially damaging host immune responses that might counteract the gene therapy component. This Review provides an overview of advances in gene vector-loaded biomaterials for articular cartilage repair. Such systems enable the sustained release of gene therapies while maintaining transduction efficacy. Strategies that harness these properties are likely to result in improved in situ cartilage tissue regeneration that could be safely translated into clinical applications in the near future.
Identifiants
pubmed: 30514957
doi: 10.1038/s41584-018-0125-2
pii: 10.1038/s41584-018-0125-2
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-29Références
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