Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.
AOM/DSS model
colitis-associated colon cancer
estrogen receptor beta
microbiota
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 06 2019
15 06 2019
Historique:
received:
01
08
2018
revised:
14
11
2018
accepted:
15
11
2018
pubmed:
6
12
2018
medline:
9
10
2019
entrez:
6
12
2018
Statut:
ppublish
Résumé
Chronic inflammation of the colon (colitis) is a risk factor for colorectal cancer (CRC). Hormone-replacement therapy reduces CRC incidences, and the estrogen receptor beta (ERβ/ESR2) has been implicated in this protection. Gut microbiota is altered in both colitis and CRC and may influence the severity of both. Here we test the hypothesis that intestinal ERβ impacts the gut microbiota. Mice with and without intestine-specific deletion of ERβ (ERβKO
Identifiants
pubmed: 30515752
doi: 10.1002/ijc.32037
pmc: PMC6519213
doi:
Substances chimiques
Estrogen Receptor beta
0
Dextran Sulfate
9042-14-2
Azoxymethane
MO0N1J0SEN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3086-3098Subventions
Organisme : NCI NIH HHS
ID : R01 CA172437
Pays : United States
Informations de copyright
© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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