Age at Onset of Metabolic Syndrome Among Women With and Without Polycystic Ovary Syndrome-Like Status.
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
29
06
2018
accepted:
28
11
2018
pubmed:
6
12
2018
medline:
28
2
2020
entrez:
6
12
2018
Statut:
ppublish
Résumé
Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population. Women with PCOS-like status (PCOSp) were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index, and high levels of antimüllerian hormone. MetS was defined according to the Adult Treatment Panel III criteria. Age at MetS onset was compared between women with and without PCOSp using an accelerated failure time model adjusted for baseline education, lifestyle factors, and midlife body weight. Among the 496 women in the analysis, 11.7% (n = 58) were determined to have PCOSp. Over a mean follow-up of 11 years, 20 women with PCOSp and 136 women without PCOSp developed MetS. After adjusting for smoking, education, and physical activity, women with PCOSp developed MetS at an age 14.4% (95% CI -22.7, -5.2) younger than women without PCOSp. The magnitude of the association was attenuated to 5.4% in models additionally adjusted for body mass index (95% CI -12.4, 2.1). Because a typical study participant without PCOSp developed MetS at 51.5 years old, 5.4% translates to almost 3 years earlier onset of MetS for a comparable woman with PCOSp. Women with PCOSp develop MetS at a younger age. Earlier screening for MetS in women with PCOS may be warranted.
Identifiants
pubmed: 30517661
pii: 5224748
doi: 10.1210/jc.2018-01428
pmc: PMC6435100
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1429-1439Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK092926
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR051384
Pays : United States
Organisme : NIOSH CDC HHS
ID : T42 OH008455
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
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