Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.
VEGFR3
integrin‐linked kinase
lymphatic vasculature
mechanical stimulation
β1 integrin
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
26
02
2018
revised:
05
11
2018
accepted:
07
11
2018
pubmed:
7
12
2018
medline:
27
12
2019
entrez:
7
12
2018
Statut:
ppublish
Résumé
Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here, we show that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-activates VEGFR3 signalling and leads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethality. Lymphatic endothelial cell (LEC)-specific deletion of
Identifiants
pubmed: 30518533
pii: embj.201899322
doi: 10.15252/embj.201899322
pmc: PMC6331728
pii:
doi:
Substances chimiques
Integrin beta1
0
integrin-linked kinase
EC 2.7.1.-
FLT4 protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-3
EC 2.7.10.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2018 The Authors.
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