Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
06
2018
accepted:
18
10
2018
revised:
28
09
2018
pubmed:
7
12
2018
medline:
16
4
2020
entrez:
7
12
2018
Statut:
ppublish
Résumé
Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia. A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios. Higher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia. Among women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.
Identifiants
pubmed: 30518800
doi: 10.1038/s41372-018-0275-8
pii: 10.1038/s41372-018-0275-8
pmc: PMC6760589
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-320Subventions
Organisme : NICHD NIH HHS
ID : R01 HD072021
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD052953
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000849
Pays : United States
Organisme : HSRD VA
ID : SDR 10-180
Pays : United States
Organisme : NHLBI NIH HHS
ID : RC2 HL101748
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD073491
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD057192
Pays : United States
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