The mouse-canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models.
ADCC, antibody-dependent cellular cytotoxicity
CDC, complement-dependent cytotoxicity
CHO, Chinese hamster ovary
CLEC-2, C-type lectin-like receptor 2
Dog podoplanin
Monoclonal antibody
Mouse-canine chimeric antibody
PBS, phosphate-buffered saline
PDPN, podoplanin
SCC, squamous cell carcinomas
dPDPN
dPDPN, dog podoplanin
mAb, monoclonal antibody
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
24
10
2018
accepted:
14
11
2018
entrez:
7
12
2018
pubmed:
7
12
2018
medline:
7
12
2018
Statut:
epublish
Résumé
Podoplanin (PDPN) is a type I transmembrane heavily glycosylated sialoglycoprotein that is expressed in normal tissues such as pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is associated with hematogenous metastasis through interactions with the C-type lectin-like receptor 2 (CLEC-2). Previously, we have reported the development of a mouse monoclonal antibody (mAb), PMab-38 (IgG
Identifiants
pubmed: 30519645
doi: 10.1016/j.bbrep.2018.11.005
pii: S2405-5808(18)30257-7
pmc: PMC6260363
doi:
Types de publication
Journal Article
Langues
eng
Pagination
23-26Commentaires et corrections
Type : ErratumIn
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