Inhibition by general anesthetic propofol of compound action potentials in the frog sciatic nerve and its chemical structure.

Action Potentials / drug effects Alcohols / pharmacology Anesthetics, General / chemistry Anesthetics, Local / pharmacology Animals Benzocaine / pharmacology Female Ketones / pharmacology Male Phenols / chemistry Ranidae Sciatic Nerve / drug effects
Analgesia Benzocaine Compound action potential Frog sciatic nerve Nerve conduction Propofol

Journal

Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264

Informations de publication

Date de publication:
03 2019
Historique:
received: 14 06 2018
accepted: 27 11 2018
pubmed: 7 12 2018
medline: 18 12 2019
entrez: 7 12 2018
Statut: ppublish

Résumé

Although the intravenous general anesthetic propofol (2,6-diisopropylphenol) has an ability to inhibit nerve conduction, this has not been fully examined. Various agents inhibit compound action potentials (CAPs) in a manner dependent on their chemical structures. To determine propofol's chemical structure that is important in nerve conduction inhibition, we examined the effects of propofol and its related compounds on fast-conducting CAPs recorded from the frog sciatic nerve by using the air-gap method. Propofol concentration-dependently reduced the peak amplitude of the CAP with a half-maximal inhibitory concentration (IC

Identifiants

DOI: 10.1007/s00210-018-01596-w PMID: 30519707
pubmed: 30519707
doi: 10.1007/s00210-018-01596-w
pii: 10.1007/s00210-018-01596-w
doi:

Substances chimiques

Alcohols 0
Anesthetics, General 0
Anesthetics, Local 0
Ketones 0
Phenols 0
Benzocaine U3RSY48JW5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

359-369

Subventions

Organisme : JSPS KAKENHI
ID : 15K08673
Pays : International

Références

Anesth Analg. 2013 Apr;116(4):932-8
pubmed: 23337417
J Pharmacol Exp Ther. 2007 Feb;320(2):828-36
pubmed: 17090703
Int J Neurosci. 2005 Mar;115(3):339-49
pubmed: 15804720
J Biol Chem. 2010 Nov 5;285(45):34781-92
pubmed: 20826794
Anesth Analg. 2008 Jan;106(1):264-9, table of contents
pubmed: 18165589
Annu Rev Pharmacol Toxicol. 2001;41:23-51
pubmed: 11264449
Neurosci Lett. 1993 Nov 12;162(1-2):93-6
pubmed: 8121645
Br J Pharmacol. 2010 Aug;160(7):1662-76
pubmed: 20649570
Eur J Pharmacol. 2018 Jan 15;819:122-128
pubmed: 29203420
Regeneration (Oxf). 2017 Jul 27;4(3):124-131
pubmed: 28975032
Br J Pharmacol. 1995 Sep;116(2):1761-8
pubmed: 8528557
Anesthesiology. 1999 Aug;91(2):512-20
pubmed: 10443615
Eur J Pharmacol. 2018 Jan 15;819:254-260
pubmed: 29225186
Life Sci. 2008 Aug 1;83(5-6):198-207
pubmed: 18593589
J Neurophysiol. 1996 Jun;75(6):2294-9
pubmed: 8793742
Eur Rev Med Pharmacol Sci. 2014 Jul;18(13):1859-68
pubmed: 25010614
Brain Res. 2005 May 10;1043(1-2):231-5
pubmed: 15862538
Eur J Pharmacol. 1991 Sep 12;208(1):75-9
pubmed: 1657621
Life Sci. 2013 Mar 14;92(6-7):368-78
pubmed: 23352977
Yakugaku Zasshi. 2009 Apr;129(4):485-93
pubmed: 19337003
Neurosci Lett. 2001 Oct 12;312(1):45-9
pubmed: 11578842
Eur J Pharmacol. 1992 Jul 21;218(1):59-68
pubmed: 1383009
Anesth Analg. 1986 Nov;65(11):1189-95
pubmed: 3490195
Neurosci Lett. 1995 Mar 31;188(3):187-90
pubmed: 7609905
Anesthesiology. 1997 Feb;86(2):428-39
pubmed: 9054261
Biomed Res Int. 2014;2014:540238
pubmed: 24707490
J Pharmacol Exp Ther. 1997 Sep;282(3):1181-6
pubmed: 9316824
Biochem Biophys Rep. 2017 Mar 23;10:145-151
pubmed: 28955742
Nature. 1994 Feb 17;367(6464):607-14
pubmed: 7509043
Eur J Pharmacol. 2009 Mar 1;605(1-3):1-8
pubmed: 19248246
Biomed Pharmacother. 2018 Jul;103:326-335
pubmed: 29665554
Pharmacol Res Perspect. 2015 Mar;3(2):e00127
pubmed: 26038703
Exp Anim. 2013;62(2):87-92
pubmed: 23615302
Eur J Pharmacol. 2011 Feb 25;653(1-3):16-20
pubmed: 21114997
Reg Anesth Pain Med. 2012 Jul-Aug;37(4):403-9
pubmed: 22430023
Br J Pharmacol. 2006 Oct;149(3):319-27
pubmed: 16921387
J Dent Anesth Pain Med. 2016 Dec;16(4):237-244
pubmed: 28879311
J Nippon Med Sch. 2017;84(4):165-169
pubmed: 28978896
J Med Chem. 1980 Dec;23(12):1350-7
pubmed: 7452689
Brain Res. 2004 Jan 23;996(2):159-67
pubmed: 14697493
Anesthesiology. 1988 Sep;69(3):348-56
pubmed: 3261954
Life Sci. 2013 Mar 14;92(6-7):359-67
pubmed: 23352972
Epilepsia. 2005 May;46(5):624-35
pubmed: 15857426
Br J Pharmacol. 1991 Nov;104(3):619-28
pubmed: 1665745
Brain Res. 2016 Jan 15;1631:147-56
pubmed: 26616339
Anesth Analg. 1997 Jun;84(6):1344-8
pubmed: 9174318
Front Hum Neurosci. 2013 Apr 09;7:136
pubmed: 23576977

Auteurs

Nobuya Magori (N)

Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Tsugumi Fujita (T)

Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Kotaro Mizuta (K)

Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Eiichi Kumamoto (E)

Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. kumamote@cc.saga-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Anesthésiques généraux › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Anesthésiques locaux › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Eucaryotes › Animaux › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Aminobenzoates › para-Aminobenzoates › Benzocaïne › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Ranidae › Inhibition by general anesthetic propofol of...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Plexus lombosacral › Nerf ischiatique › Inhibition by general anesthetic propofol of...