Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice.
Animals
Blood Cell Count
Bone Marrow
/ radiation effects
Cosmic Radiation
Dose-Response Relationship, Radiation
Hematopoiesis
/ radiation effects
Hematopoietic Stem Cells
/ radiation effects
Humans
Mice
Mice, Inbred NOD
Models, Animal
Neoplasms, Radiation-Induced
/ genetics
Relative Biological Effectiveness
Space Flight
Spleen
/ radiation effects
Journal
Radiation research
ISSN: 1938-5404
Titre abrégé: Radiat Res
Pays: United States
ID NLM: 0401245
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
7
12
2018
medline:
6
4
2019
entrez:
7
12
2018
Statut:
ppublish
Résumé
Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. In this study, we irradiated humanized mice with 0.4 Gy of 350 MeV/n
Identifiants
pubmed: 30520704
pii: 10.1667/RR15148.1
doi: 10.1667/RR15148.1
pmc: PMC6555159
mid: NIHMS1011346
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-175Subventions
Organisme : NIH HHS
ID : P30CA013696
Pays : United States
Organisme : NIH HHS
ID : U19 AI AI67798
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI067773
Pays : United States
Organisme : NIH HHS
ID : U19 AI067773
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI067798
Pays : United States
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