p53-Family Proteins in Odontogenic Cysts: An Immunohistochemical Study.
Adolescent
Adult
Aged
Epithelial Cells
/ metabolism
Female
Gene Expression Regulation, Neoplastic
/ genetics
Humans
Immunohistochemistry
Male
Membrane Proteins
/ genetics
Middle Aged
Odontogenic Cysts
/ metabolism
Protein Isoforms
/ metabolism
Retrospective Studies
Tumor Protein p73
/ genetics
Tumor Suppressor Protein p53
/ genetics
Young Adult
Journal
Applied immunohistochemistry & molecular morphology : AIMM
ISSN: 1533-4058
Titre abrégé: Appl Immunohistochem Mol Morphol
Pays: United States
ID NLM: 100888796
Informations de publication
Date de publication:
Historique:
pubmed:
7
12
2018
medline:
11
5
2021
entrez:
7
12
2018
Statut:
ppublish
Résumé
The present study investigated the immunohistochemical expression of p53, p63, and p73 in different types of odontogenic cysts (OC), a group of common intraosseous jaw lesions, to provide a better understanding of p53-family functions in odontogenic lesions. We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). The epithelial expression of p53-family members was evaluated both in the basal-parabasal and in the superficial layers, measuring the percentage of positive cells and the value of expression intensity. The expression of p53-family members showed a significant difference between the "OKC" and "non-OKC" groups. In particular, p53 positivity in the basal-parabasal layers, as well as p63 positivity in the superficial layers, were more common in OKC (P<0.0001; P=0.0237). p73 expression in the superficial layers was significantly more expressed in the "non-OKC" group (P<0.0001). No significant differences of staining intensity scores were reported between the groups. The Spearman test showed a positive correlation between p53 and p73 expression at the basal-parabasal level in all cysts (r=0.6626; P<0.0001). These results showed a significantly different expression of p53-family members in OC groups, in particular between the "OKC" and "non-OKC" groups, suggesting the existence of a p53-family pathway in the epithelial lining of OC.
Identifiants
pubmed: 30520832
doi: 10.1097/PAI.0000000000000727
pii: 00129039-202005000-00006
doi:
Substances chimiques
CKAP4 protein, human
0
Membrane Proteins
0
Protein Isoforms
0
TP53 protein, human
0
TP73 protein, human
0
Tumor Protein p73
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-375Références
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