Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics.
Journal
Bioinformatics (Oxford, England)
ISSN: 1367-4811
Titre abrégé: Bioinformatics
Pays: England
ID NLM: 9808944
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
01
05
2018
revised:
06
09
2018
accepted:
04
12
2018
pubmed:
7
12
2018
medline:
12
6
2020
entrez:
7
12
2018
Statut:
ppublish
Résumé
Large biobanks linking phenotype to genotype have led to an explosion of genetic association studies across a wide range of phenotypes. Sharing the knowledge generated by these resources with the scientific community remains a challenge due to patient privacy and the vast amount of data. Here, we present Global Biobank Engine (GBE), a web-based tool that enables exploration of the relationship between genotype and phenotype in biobank cohorts, such as the UK Biobank. GBE supports browsing for results from genome-wide association studies, phenome-wide association studies, gene-based tests and genetic correlation between phenotypes. We envision GBE as a platform that facilitates the dissemination of summary statistics from biobanks to the scientific and clinical communities. GBE currently hosts data from the UK Biobank and can be found freely available at biobankengine.stanford.edu.
Identifiants
pubmed: 30520965
pii: 5231855
doi: 10.1093/bioinformatics/bty999
pmc: PMC6612820
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2495-2497Subventions
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG009080
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NLM NIH HHS
ID : T32 LM012409
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM007033
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010140
Pays : United States
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press.
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