APOE-ε4 Genotype is Associated with Elevated Post-Concussion Symptoms in Military Veterans with a Remote History of Mild Traumatic Brain Injury.
APOE gene
Genetics
Head injury
Military Veterans
Neurobehavioral Symptom Inventory
Post-concussion symptoms
mTBI
Journal
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
ISSN: 1873-5843
Titre abrégé: Arch Clin Neuropsychol
Pays: United States
ID NLM: 9004255
Informations de publication
Date de publication:
26 Jul 2019
26 Jul 2019
Historique:
received:
11
05
2018
revised:
28
07
2018
pubmed:
7
12
2018
medline:
24
4
2020
entrez:
7
12
2018
Statut:
ppublish
Résumé
We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI). Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). The Neurobehavioral Symptom Inventory (NSI) was the primary outcome measure, from which a total score was derived, as well as three symptom clusters (somatic, cognitive, and affective). ANCOVAs showed a significant main effect of ε4 genotype on the NSI total score and somatic symptom cluster after adjusting for posttraumatic stress symptoms and mTBI history (p = .019-.028, ηp2 = .064-.073), such that ε4+ Veterans endorsed significantly greater symptoms than ε4- Veterans. Our findings suggest that genetic risk may help to explain the poorer long-term outcomes often observed in this population.
Identifiants
pubmed: 30521018
pii: 5231884
doi: 10.1093/arclin/acy082
pmc: PMC6659168
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
706-712Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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