Skeletal phenotype of the neuropeptide Y knockout mouse.
Bone
Bone strength
Conditional mouse
Cortical bone
Neuropeptide Y (NPY)
Journal
Neuropeptides
ISSN: 1532-2785
Titre abrégé: Neuropeptides
Pays: Netherlands
ID NLM: 8103156
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
09
08
2018
revised:
04
11
2018
accepted:
28
11
2018
pubmed:
14
12
2018
medline:
12
2
2019
entrez:
8
12
2018
Statut:
ppublish
Résumé
Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which cells within the skeleton express Npy and establish a model that will enable us to differentiate effects of NPY derived from different cell types. We have generated the NPY floxed (NPY
Identifiants
pubmed: 30522780
pii: S0143-4179(18)30137-9
doi: 10.1016/j.npep.2018.11.009
pmc: PMC6326877
mid: NIHMS1515776
pii:
doi:
Substances chimiques
Neuropeptide Y
0
Receptors, Neuropeptide Y
0
Alkaline Phosphatase
EC 3.1.3.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-88Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR055607
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070813
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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