Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages.
Kdo2-lipid A
cytokines
lipid droplet
phagocytosis
phospholipid
triacylglycerol
Journal
The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R
Informations de publication
Date de publication:
11 01 2019
11 01 2019
Historique:
received:
21
05
2018
revised:
03
12
2018
accepted:
05
12
2018
pubmed:
14
12
2018
medline:
5
9
2019
entrez:
8
12
2018
Statut:
epublish
Résumé
Macrophage classical M1 activation via TLR4 triggers a variety of responses to achieve the elimination of foreign pathogens. During this process, there is also an increase in lipid droplets which contain large quantities of triacylglycerol (TAG) and phospholipid (PL). The functional consequences of this increment in lipid mass are poorly understood. Here, we studied the contribution of glycerolipid synthesis to lipid accumulation, focusing specifically on the first and rate-limiting enzyme of the pathway: glycerol-3-phosphate acyltransferase (GPAT). Using bone marrow-derived macrophages (BMDMs) treated with Kdo
Identifiants
pubmed: 30523059
pii: BCJ20180381
doi: 10.1042/BCJ20180381
doi:
Substances chimiques
Phospholipids
0
Triglycerides
0
GPAT4 protein, mouse
EC 2.3.1.15
Glycerol-3-Phosphate O-Acyltransferase
EC 2.3.1.15
1-Acylglycerol-3-Phosphate O-Acyltransferase
EC 2.3.1.51
GPAT3 protein, mouse
EC 2.3.1.51
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-99Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.