Overcoming Endosomal Entrapment in Drug Delivery.
Journal
Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319
Informations de publication
Date de publication:
20 02 2019
20 02 2019
Historique:
pubmed:
12
12
2018
medline:
26
11
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids generally rely on the endocytic pathway as the major uptake mechanism, resulting in their entrapment inside the endosome and lysosome. The recent discovery of cell-penetrating molecules of exceptionally high endosomal escape and cytosolic delivery efficiencies and elucidation of their mechanism of action represent major breakthroughs in this field. In this Topical Review, we provide an overview of the recent progress in understanding and enhancing the endosomal escape process and the new opportunities opened up by these recent findings.
Identifiants
pubmed: 30525488
doi: 10.1021/acs.bioconjchem.8b00778
pmc: PMC6501178
mid: NIHMS1026345
doi:
Substances chimiques
Drug Carriers
0
Peptides
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-283Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM122459
Pays : United States
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