Single-Neuron Correlates of Error Monitoring and Post-Error Adjustments in Human Medial Frontal Cortex.
anterior cingulate cortex
cognitive control
error monitoring
executive function
human intracranial
human single-neuron
medial frontal cortex
post-error slowing
pre-supplementary motor area
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
14
08
2018
revised:
12
10
2018
accepted:
08
11
2018
pubmed:
12
12
2018
medline:
21
8
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Humans can self-monitor errors without explicit feedback, resulting in behavioral adjustments on subsequent trials such as post-error slowing (PES). The error-related negativity (ERN) is a well-established macroscopic scalp EEG correlate of error self-monitoring, but its neural origins and relationship to PES remain unknown. We recorded in the frontal cortex of patients performing a Stroop task and found neurons that track self-monitored errors and error history in dorsal anterior cingulate cortex (dACC) and pre-supplementary motor area (pre-SMA). Both the intracranial ERN (iERN) and error neuron responses appeared first in pre-SMA, and ∼50 ms later in dACC. Error neuron responses were correlated with iERN amplitude on individual trials. In dACC, such error neuron-iERN synchrony and responses of error-history neurons predicted the magnitude of PES. These data reveal a human single-neuron correlate of the ERN and suggest that dACC synthesizes error information to recruit behavioral control through coordinated neural activity.
Identifiants
pubmed: 30528064
pii: S0896-6273(18)31007-9
doi: 10.1016/j.neuron.2018.11.016
pmc: PMC6354767
mid: NIHMS1512816
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Pagination
165-177.e5Subventions
Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110831
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS103792
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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