IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells.
cardiac remodeling
insulin-like growth factor 1
macrophage polarization
myeloid cells
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
24
07
2018
revised:
25
10
2018
accepted:
26
10
2018
pubmed:
12
12
2018
medline:
18
12
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute myocardial infarction (AMI), but the underlying mechanisms and cellular targets are not fully understood. Here we demonstrate that short-term IGF1 treatment for 3 days after AMI improved cardiac function after 1 and 4 weeks. Regional wall motion was improved in ischemic segments, scar size was reduced, and capillary density increased in the infarcted area and the border zone. Unexpectedly, inducible inactivation of the IGF1 receptor (IGF1R) in cardiomyocytes did not attenuate the protective effect of IGF1. Sequential cardiac transcriptomic analysis indicated an altered myeloid cell response in the acute phase after AMI, and, notably, myeloid-cell Igf1r
Identifiants
pubmed: 30528085
pii: S1525-0016(18)30527-6
doi: 10.1016/j.ymthe.2018.10.020
pmc: PMC6319026
pii:
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Receptor, IGF Type 1
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-58Informations de copyright
Copyright © 2018 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.
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