Short-Term Effects of Dry Extracts of Artichokeand Berberis in Hypercholesterolemic Patients Without Cardiovascular Disease.
Journal
The American journal of cardiology
ISSN: 1879-1913
Titre abrégé: Am J Cardiol
Pays: United States
ID NLM: 0207277
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
12
10
2018
revised:
08
11
2018
accepted:
15
11
2018
pubmed:
12
12
2018
medline:
18
12
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Hypercholesterolemia represents one of the main reversible cardiovascular risk factors. In this pilot clinical trial, we have tested the short-term efficacy and safety of a new combined cholesterol-lowering nutraceutical containing artichoke dry extract and berberine at enhanced bioavailability in subjects with moderate polygenic hypercholesterolemia in primary prevention for cardiovascular disease. After 2 months of treatment, the tested nutraceutical induced a significant reduction in plasma total cholesterol (-19%), low-density lipoprotein cholesterol (-16%), non-high-density lipoprotein cholesterol (-19%) and triglyceride levels (-15%), in association with a standardized control diet. No side effect has been observed during the trial. In conclusion, on the short-term, the tested nutraceutical has been shown to be well tolerated and effective, even if not containing any statin-like compound.
Identifiants
pubmed: 30528419
pii: S0002-9149(18)32099-X
doi: 10.1016/j.amjcard.2018.11.018
pii:
doi:
Substances chimiques
Plant Extracts
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
588-591Informations de copyright
Copyright © 2018. Published by Elsevier Inc.