Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview.
Aging
/ physiology
Animals
Bone and Bones
/ metabolism
Cell Differentiation
Gene Expression Regulation
Gene Targeting
Humans
Inflammation
/ physiopathology
Mesenchymal Stem Cells
/ physiology
Mice
MicroRNAs
/ genetics
Musculoskeletal System
/ physiopathology
Osteoporosis
/ physiopathology
Oxidative Stress
/ physiology
MiR-200 family
MicroRNA-141
aging
musculoskeletal
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
16
07
2018
revised:
31
10
2018
accepted:
05
12
2018
pubmed:
12
12
2018
medline:
8
6
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3' UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Additionally, with aging, it is noted that there is dysregulation in the normal function of stem cell differentiation, bone formation/degradation, chondrocyte function, and muscle degeneration. Due to the change in expression of miRNA in degenerative musculoskeletal pathology, it is believed that these molecules may be at least partially responsible for cellular dysfunction. A number of miRNAs have already been identified to play a role in osteoarthritis, osteoporosis and sarcopenia. One miRNA that has become of interest recently is miRNA 141. The purpose of this article is to review the current literature available on miRNA 141 and how it could play a role in osteoporosis, osteoarthritis and musculoskeletal pathology overall.
Identifiants
pubmed: 30528652
pii: S0047-6374(18)30149-0
doi: 10.1016/j.mad.2018.12.001
pmc: PMC6998035
mid: NIHMS1516567
pii:
doi:
Substances chimiques
MIRN141 microRNA, human
0
MIRN200 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-15Subventions
Organisme : NIA NIH HHS
ID : P01 AG036675
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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