Correlation and temporal variability of urinary biomarkers of chemicals among couples: Implications for reproductive epidemiological studies.
Chemicals
Correlation
Couple
Mercury
Organophosphate flame retardants
Phenol
Phthalate
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
13
08
2018
revised:
08
11
2018
accepted:
29
11
2018
pubmed:
12
12
2018
medline:
14
6
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Exposure to some environmental chemicals is ubiquitous and linked to a variety of adverse outcomes, including children's health. While few studies have assessed the contribution of both male and female exposures to children's health, understanding the patterns of couple's exposure is needed to understand their joint effects. We assessed the correlation patterns between male and female partners' concentrations of 37 environmental chemical biomarkers. We also assessed the temporal reliability of the biomarkers within couples. We calculated Spearman pairwise correlations between specific gravity adjusted urinary biomarker concentrations and hair mercury concentrations among 380 couples enrolled in the Environment and Reproductive Health (EARTH) study at the Massachusetts General Hospital Fertility Center (2004-2017). We calculated intra-class correlation coefficients (ICCs) for couple's biomarkers to assess the temporal variability of these exposures within a couple using multiple paired-samples from couples. All biomarkers were positively correlated within couples (range: 0.05 for tert-butylphenyl phenyl phosphate to 0.66 for triclosan). In general, the biomarkers with the highest within couple correlation were those of chemicals for which diet (e.g., di(2-ethylhexyl) phthalate), personal care products use (e.g., triclosan, benzophenone-3), and the indoor environment (e.g., 2,5-dichlorophenol) are considered primary exposure sources. Most other biomarkers were moderately correlated (0.3-<0.6). Similar patterns of temporal reliability were observed across biomarkers. Urinary concentrations of several biomarkers were mostly moderately correlated within couples, suggesting similar exposure sources. Future epidemiological studies should collect samples from both partners to be able to accurately determine the contribution of maternal and paternal exposures to offspring health.
Sections du résumé
BACKGROUND
Exposure to some environmental chemicals is ubiquitous and linked to a variety of adverse outcomes, including children's health. While few studies have assessed the contribution of both male and female exposures to children's health, understanding the patterns of couple's exposure is needed to understand their joint effects.
OBJECTIVE
We assessed the correlation patterns between male and female partners' concentrations of 37 environmental chemical biomarkers. We also assessed the temporal reliability of the biomarkers within couples.
METHODS
We calculated Spearman pairwise correlations between specific gravity adjusted urinary biomarker concentrations and hair mercury concentrations among 380 couples enrolled in the Environment and Reproductive Health (EARTH) study at the Massachusetts General Hospital Fertility Center (2004-2017). We calculated intra-class correlation coefficients (ICCs) for couple's biomarkers to assess the temporal variability of these exposures within a couple using multiple paired-samples from couples.
RESULTS
All biomarkers were positively correlated within couples (range: 0.05 for tert-butylphenyl phenyl phosphate to 0.66 for triclosan). In general, the biomarkers with the highest within couple correlation were those of chemicals for which diet (e.g., di(2-ethylhexyl) phthalate), personal care products use (e.g., triclosan, benzophenone-3), and the indoor environment (e.g., 2,5-dichlorophenol) are considered primary exposure sources. Most other biomarkers were moderately correlated (0.3-<0.6). Similar patterns of temporal reliability were observed across biomarkers.
CONCLUSIONS
Urinary concentrations of several biomarkers were mostly moderately correlated within couples, suggesting similar exposure sources. Future epidemiological studies should collect samples from both partners to be able to accurately determine the contribution of maternal and paternal exposures to offspring health.
Identifiants
pubmed: 30529890
pii: S0160-4120(18)31822-1
doi: 10.1016/j.envint.2018.11.078
pmc: PMC6358023
mid: NIHMS1004705
pii:
doi:
Substances chimiques
Biomarkers
0
Environmental Pollutants
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-188Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES027408
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES009718
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022955
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES024381
Pays : United States
Organisme : NIEHS NIH HHS
ID : K99 ES026648
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES026648
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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