Nutrient sulfur acquisition strategies employed by bacterial pathogens.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
29
08
2018
revised:
04
11
2018
accepted:
07
11
2018
pubmed:
12
12
2018
medline:
6
2
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Pathogens have evolved elegant mechanisms to acquire essential nutrients from host environments. Sulfur is a requirement for bacterial growth and inorganic and organic sulfur-containing metabolites are abundant within the host-pathogen interface. A growing body of evidence suggests that pathogens are capable of scavenging both types of sulfur sources to fulfill the nutritional requirement. While therapeutic strategies focusing on inhibiting inorganic sulfate assimilation and cysteine synthesis show promise in vitro, in vivo efficacy maybe limited due to the diversity of host-derived sulfur sources and the fact that most pathogens are capable of acquiring multiple sources of sulfur.
Identifiants
pubmed: 30530037
pii: S1369-5274(18)30095-X
doi: 10.1016/j.mib.2018.11.002
pii:
doi:
Substances chimiques
Sulfur Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-58Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.