Recent advances of tetrazole derivatives as potential anti-tubercular and anti-malarial agents.
Anti-malarial
Anti-tubercular
Hybrid compounds
Structure-activity relationship
Tetrazole
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Feb 2019
01 Feb 2019
Historique:
received:
04
11
2018
revised:
30
11
2018
accepted:
01
12
2018
pubmed:
12
12
2018
medline:
12
2
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Tetrazole, a bioisostere of the carboxylic acid group, can replace the carboxyl group in drugs to increase the lipophilicity, bioavailability and reduce side effects. Tetrazole derivatives possess a broad-spectrum of biological properties including anti-tubercular and anti-malarial activities, and some tetrazole-based compounds have already been used in clinics for the treatment of various diseases. Therefore, tetrazole is an important pharmacophore in the development of new drugs. This review covers the recent advances of tetrazole derivatives as potential anti-tubercular and anti-malarial agents, and the structure-activity relationship is also discussed for the further rational design of tetrazole derivatives.
Identifiants
pubmed: 30530192
pii: S0223-5234(18)31038-9
doi: 10.1016/j.ejmech.2018.12.001
pii:
doi:
Substances chimiques
Antimalarials
0
Antitubercular Agents
0
Tetrazoles
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-412Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.