Phytochemicals: Current strategy to sensitize cancer cells to cisplatin.
Cancer
Cisplatin
Phytochemicals
Resistance
Toxicity
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
08
2018
revised:
11
11
2018
accepted:
02
12
2018
pubmed:
12
12
2018
medline:
23
4
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Cisplatin-based chemotherapeutic regimens are the most frequently used adjuvant treatments for many types of cancer. However, the development of chemoresistance to cisplatin results in treatment failure. Despite the significant developments in understanding the mechanisms of cisplatin resistance, effective strategies to enhance the chemosensitivity of cisplatin are lacking. Phytochemicals are naturally occurring plant-based compounds that can augment the anti-cancer activity of cisplatin, with minimal side effects. Notably, some novel phytochemicals, such as curcumin, not only increase the efficacy of cisplatin but also decrease toxicity induced by cisplatin. However, the exact mechanisms underlying this process remain unclear. In this review, we discussed the progress made in utilizing phytochemicals to enhance the anti-cancer efficacy of cisplatin. We also presented some ideal phytochemicals as novel agents for counteracting cisplatin-induced organ damage.
Identifiants
pubmed: 30530287
pii: S0753-3322(18)36133-X
doi: 10.1016/j.biopha.2018.12.010
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Phytochemicals
0
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
518-527Informations de copyright
Copyright © 2018. Published by Elsevier Masson SAS.