Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.
ATP-Binding Cassette Transporters
/ chemistry
Adenosine Triphosphatases
/ chemistry
Biological Transport, Active
Glucosylceramides
/ chemistry
HeLa Cells
Humans
Membrane Transport Proteins
/ chemistry
Models, Molecular
Mutagenesis, Site-Directed
Protein Domains
Saccharomyces cerevisiae
/ enzymology
Saccharomyces cerevisiae Proteins
/ chemistry
Schizosaccharomyces
/ enzymology
Schizosaccharomyces pombe Proteins
/ chemistry
P4-ATPase
cerebroside
enzyme mechanism
flippase
glucosylceramide
glycolipid
glycosphingolipids
lipid transport
membrane asymmetry
membrane bilayer
membrane biology
sphingolipid
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
16
09
2018
revised:
29
11
2018
pubmed:
12
12
2018
medline:
27
6
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the membrane bilayer and are involved in signal transduction, cell division, and vesicular transport. Mutations in flippase genes cause or contribute to a host of diseases, such as cholestasis, neurological deficits, immunological dysfunction, and metabolic disorders. Genome-wide association studies have shown that
Identifiants
pubmed: 30530492
pii: S0021-9258(20)36829-0
doi: 10.1074/jbc.RA118.005876
pmc: PMC6369285
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Glucosylceramides
0
Membrane Transport Proteins
0
Saccharomyces cerevisiae Proteins
0
Schizosaccharomyces pombe Proteins
0
Adenosine Triphosphatases
EC 3.6.1.-
Dnf2 protein, S cerevisiae
EC 3.6.1.3
ATP10A protein, human
EC 7.6.2.1
Dnf1 protein, S cerevisiae
EC 7.6.2.1
Banques de données
PDB
['3W5D', '1MHS', '4WIT', '3B9B', '3IXZ', '2ZXE', '3B8C', '3B8E']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1794-1806Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM116310
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH065215
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM107978
Pays : United States
Informations de copyright
© 2019 Roland et al.
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