Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.

Aging / genetics Animals Cell Cycle Proteins / genetics Cell Proliferation Chromosomal Proteins, Non-Histone / genetics DNA-Binding Proteins Hematopoietic Stem Cells / immunology Inflammation / genetics Mice Mice, Knockout NF-kappa B / genetics Nuclear Proteins / genetics Phosphoproteins / genetics Signal Transduction / genetics Cohesins

Journal

The Journal of experimental medicine

ISSN: 1540-9538

Titre abrégé: J Exp Med

Pays: United States

ID NLM: 2985109R

Informations de publication

Date de publication:
07 01 2019

Historique:

received: 06 08 2018

revised: 06 11 2018

accepted: 19 11 2018

pubmed: 12 12 2018

medline: 7 11 2019

entrez: 12 12 2018

Statut: ppublish

Résumé

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies

Identifiants

DOI: 10.1084/jem.20181505 PMID: 30530755 PMC: PMC6314529

pubmed: 30530755

pii: jem.20181505

doi: 10.1084/jem.20181505

pmc: PMC6314529

doi:

Substances chimiques

Cell Cycle Proteins 0

Chromosomal Proteins, Non-Histone 0

DNA-Binding Proteins 0

NF-kappa B 0

Nuclear Proteins 0

Phosphoproteins 0

Rad21 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

152-175

Informations de copyright

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