Aging and Hyperglycemia Intensify Dyslipidemia-Induced Oxidative Stress and Inflammation in Rats: Assessment of Restorative Potentials of ALA and EPA + DHA.
Aging
Animals
Biomarkers
/ blood
Diabetes Mellitus, Experimental
/ chemically induced
Docosahexaenoic Acids
Dyslipidemias
/ complications
Eicosapentaenoic Acid
Fatty Acids, Omega-3
/ therapeutic use
Hyperglycemia
/ congenital
Inflammation
/ drug therapy
Oxidative Stress
/ drug effects
Rats
alpha-Linolenic Acid
dyslipidemia
hyperglycemia
inflammation
n-3 fatty acids
oxidative stress
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
12
12
2018
medline:
18
12
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Effect of aging and hyperglycemia on oxidative stress (OS) and inflammation in dyslipidemic conditions has not been elucidated. Hence, in this study, we assessed the implications of aging, hyperglycemia, and also the dietary effect of n-3 fatty acids (α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)) on OS and inflammation in dyslipidemic rats. Dyslipidemia was induced in young and aged rats by feeding high-fat lard (HFL) diet. Diabetes was induced in young dyslipidemic rats by administering streptozotocin 30 days after the induction of dyslipidemia. Experimental groups received diets containing canola oil (HF + CNO) and fish oil (HF + FO) as a source of ALA and EPA + DHA respectively. After 60 days of feeding rats with their respective diets, OS and inflammatory markers in serum were assessed. Dyslipidemia caused significant (p < 0.05) increase in OS (lipid peroxidation, nitric oxide, and protein carbonyl), pro-inflammatory cytokine (CRP, IL-1β, MCP-1, and TNF-α), and eicosanoid (PGE
Identifiants
pubmed: 30535619
doi: 10.1007/s10753-018-0949-6
pii: 10.1007/s10753-018-0949-6
doi:
Substances chimiques
Biomarkers
0
Fatty Acids, Omega-3
0
alpha-Linolenic Acid
0RBV727H71
Docosahexaenoic Acids
25167-62-8
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
946-952Subventions
Organisme : Council of Scientific and Industrial Research
ID : BSC 0404
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