Sialyl-LacNAc-PNA⋅DNA Concatamers by Rolling-Circle Amplification as Multivalent Inhibitors of Influenza A Virus Particles.

Antiviral Agents / chemistry DNA, Circular / chemistry Hemagglutinin Glycoproteins, Influenza Virus / metabolism Influenza A virus / drug effects Nucleic Acid Amplification Techniques Peptide Nucleic Acids / chemistry Virion / drug effects
antiviral agents influenza inhibitors multivalency nucleic acids rolling-circle amplification

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
18 01 2019
Historique:
received: 22 10 2018
pubmed: 12 12 2018
medline: 9 11 2019
entrez: 12 12 2018
Statut: ppublish

Résumé

The surfaces of influenza A virus (IAV) particles are packed with hundreds of homo-trimeric hemagglutinins (HAs). Monovalent sugars have low affinity for HA, but distance-optimized bivalent sialyl-LacNAc (SLN) conjugates bind it with 10

Identifiants

DOI: 10.1002/cbic.201800643 PMID: 30536690
pubmed: 30536690
doi: 10.1002/cbic.201800643
doi:

Substances chimiques

Antiviral Agents 0
DNA, Circular 0
Hemagglutinin Glycoproteins, Influenza Virus 0
Peptide Nucleic Acids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

159-165

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Victor Bandlow (V)

Institute of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.

Daniel Lauster (D)

Institute of Biology, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany.

Kai Ludwig (K)

Institute of Chemistry and Biochemistry and Core Facility BioSupraMol, Freie Universität Berlin, Fabeckstrasse 36a, 14195, Berlin, Germany.

Malte Hilsch (M)

Institute of Biology, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany.

Valentin Reiter-Scherer (V)

Institute of Physics, Humboldt-Universität zu Berlin, Newtonstrasse 15, 12489, Berlin, Germany.

Jürgen P Rabe (JP)

Institute of Physics, Humboldt-Universität zu Berlin, Newtonstrasse 15, 12489, Berlin, Germany.

Christoph Böttcher (C)

Institute of Chemistry and Biochemistry and Core Facility BioSupraMol, Freie Universität Berlin, Fabeckstrasse 36a, 14195, Berlin, Germany.

Andreas Herrmann (A)

Institute of Biology, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany.

Oliver Seitz (O)

Institute of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.
ORCID: 0000-0003-0611-4810

Articles similaires

Advances research in porcine enteric coronavirus therapies and antiviral drugs.

Jixiang Liang, Weihang Xu, Xiaoming Pan et al.
1.00
Animals Swine Antiviral Agents Swine Diseases Coronavirus Infections

Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans.

Joy Jiang, Meredith S Shiels, Donna Rivera et al.
1.00
Humans Carcinoma, Hepatocellular Liver Neoplasms Aged United States

Point-of-care test of blood Plasmodium RNA within a Pasteur pipette using a novel isothermal amplification without nucleic acid purification.

Lyu Xie, Jiyu Xu, Lihua Fan et al.
1.00
Nucleic Acid Amplification Techniques Humans Point-of-Care Testing Sensitivity and Specificity Malaria

A systematic review of laboratory investigations into the pathogenesis of avian influenza viruses in wild avifauna of North America.

Matthew Gonnerman, Christina Leyson, Jeffery D Sullivan et al.
1.00
Animals Influenza in Birds Animals, Wild Birds Influenza A virus

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN circulaire › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Glycoprotéine hémagglutinine du virus influenza › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Acides nucléiques peptidiques › Sialyl-LacNAc-PNA⋅DNA Concatamers by...
questionsmedicales.fr › Structures virales › Virion › Sialyl-LacNAc-PNA⋅DNA Concatamers by...