Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.
hair follicle stem cells
hair greying
hair regeneration
melanocyte stem cells
pigmentation disorders
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
26
09
2018
revised:
27
11
2018
accepted:
05
12
2018
pubmed:
12
12
2018
medline:
9
9
2020
entrez:
12
12
2018
Statut:
ppublish
Résumé
Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate and keep quiescence to control and coordinate tissue homeostasis, repair and regeneration. In synchrony with hair follicle stem cells, melanocyte stem cells in the hair follicles undergo cyclic activation, degeneration and resting phases, to pigment the hairs and to preserve the stem cells. Disorder of melanocytes results in severe skin problems such as canities, vitiligo and even melanoma. Here, we compare and summarize recent discoveries about melanocyte in the skin, particularly in the hair follicle. A better understanding of the physiological and pathological regulation of melanocyte and melanocyte stem cell behaviours will help to guide the clinical applications in regenerative medicine.
Identifiants
pubmed: 30537004
doi: 10.1111/exd.13856
pmc: PMC6488374
mid: NIHMS1001436
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
395-405Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR047364
Pays : United States
Organisme : National Natural Science Foundation of Hubei Province
ID : 2016CFB348
Pays : International
Organisme : NIAMS NIH HHS
ID : R01 AR060306
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81602782
Pays : International
Organisme : NIGMS NIH HHS
ID : R01 GM125322
Pays : United States
Organisme : Projects Funded by China Postdoctoral Science Foundation
ID : 2016M590866
Pays : International
Organisme : "Drug Development Center, China Medical University" from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan
Pays : International
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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