A New Drug Delivery System Based on Tauroursodeoxycholic Acid and PEDOT.
conductive polymers
drug delivery
electrochemistry
electrodeposition
neural recording
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
11 Feb 2019
11 Feb 2019
Historique:
received:
22
10
2018
pubmed:
12
12
2018
medline:
15
8
2019
entrez:
12
12
2018
Statut:
ppublish
Résumé
Localized drug delivery represents one of the most challenging uses of systems based on conductive polymer films. Typically, anionic drugs are incorporated within conductive polymers through electrostatic interaction with the positively charged polymer. Following this approach, the synthetic glucocorticoid dexamethasone phosphate is often delivered from neural probes to reduce the inflammation of the surrounding tissue. In light of the recent literature on the neuroprotective and anti-inflammatory properties of tauroursodeoxycholic acid (TUDCA), for the first time, this natural bile acid was incorporated within poly(3,4-ethylenedioxythiophene) (PEDOT). The new material, PEDOT-TUDCA, efficiently promoted an electrochemically controlled delivery of the drug, while preserving optimal electrochemical properties. Moreover, the low cytotoxicity observed with viability assays, makes PEDOT-TUDCA a good candidate for prolonging the time span of chronic neural recording brain implants.
Identifiants
pubmed: 30537238
doi: 10.1002/chem.201805285
doi:
Substances chimiques
Biocompatible Materials
0
Bridged Bicyclo Compounds, Heterocyclic
0
Polymers
0
poly(3,4-ethylene dioxythiophene)
0
Taurochenodeoxycholic Acid
516-35-8
ursodoxicoltaurine
60EUX8MN5X
Types de publication
Journal Article
Langues
eng
Pagination
2322-2329Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.