Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.
ENaC
UT-A1
UT-A3
nitric oxide
renal inner medulla
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
pubmed:
13
12
2018
medline:
10
1
2020
entrez:
13
12
2018
Statut:
ppublish
Résumé
Although the role of urea in urine concentration is known, the effect of urea handling by the urea transporters (UTs), UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacking both UT-A1 and UT-A3 (UT-A1/A3 KO) have significantly lower serum sodium and higher urinary sodium. Protein expression of renal sodium transporters is unchanged among all three genotypes. WT, UT-A3 KO, and UT-A1/A3 KO acutely respond to hydrochlorothiazide and furosemide; however, UT-A1/A3 KO fail to show a diuretic or natriuretic response following amiloride administration, indicating that baseline epithelial Na
Identifiants
pubmed: 30539654
doi: 10.1152/ajprenal.00166.2018
pmc: PMC6459308
doi:
Substances chimiques
Epithelial Sodium Channels
0
Membrane Transport Proteins
0
Nitric Oxide
31C4KY9ESH
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F539-F549Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK041707
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110409
Pays : United States
Organisme : NIDDK NIH HHS
ID : R25 DK101390
Pays : United States
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