Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.


Journal

Journal of pediatric gastroenterology and nutrition
ISSN: 1536-4801
Titre abrégé: J Pediatr Gastroenterol Nutr
Pays: United States
ID NLM: 8211545

Informations de publication

Date de publication:
01 2019
Historique:
pubmed: 13 12 2018
medline: 18 3 2020
entrez: 13 12 2018
Statut: ppublish

Résumé

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. This report is intended to provide guidance for FMT in the treatment of rCDI in pediatric patients.

Identifiants

pubmed: 30540704
doi: 10.1097/MPG.0000000000002205
pmc: PMC6475090
mid: NIHMS1016802
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

130-143

Subventions

Organisme : NCATS NIH HHS
ID : KL2 TR002245
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081197
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

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Auteurs

Zev H Davidovics (ZH)

Department of Pediatric Gastroenterology, Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Farmington, CT.

Sonia Michail (S)

Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.

Maribeth R Nicholson (MR)

D. Brent Polk Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN.

Larry K Kociolek (LK)

Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.

Nikhil Pai (N)

Division of Pediatric Gastroenterology and Nutrition, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Richard Hansen (R)

Department of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, Scotland.

Tobias Schwerd (T)

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

Aldo Maspons (A)

VeMiDoc, LLC, El Paso, TX.

Raanan Shamir (R)

Institute for Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Hania Szajewska (H)

Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland.

Nikhil Thapar (N)

Department of Paediatric Gastroenterology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.

Tim de Meij (T)

Department of Paediatric Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands.

Alexis Mosca (A)

Division of Pediatric Gastroenterology and Nutrition, Robert Debré Hospital (APHP).
French Group of Fecal Transplantation, St Antoine Hospital (APHP), Paris, France.

Yvan Vandenplas (Y)

KidZ Health Castle, Universitair Ziekenuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Stacy A Kahn (SA)

Division of Gastroetenterology and Nutrition, Inflammatory Bowel Disease Center, Boston Children's Hospital, Harvard Medical School, Boston, MA.

Richard Kellermayer (R)

Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.

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