The monocytosis during human leptospirosis is associated with modest immune cell activation states.
HLA-DR
Innate immunity
Leptospirosis
Monocytes
Phagocytosis
Journal
Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
25
06
2018
accepted:
07
12
2018
pubmed:
14
12
2018
medline:
11
1
2020
entrez:
14
12
2018
Statut:
ppublish
Résumé
Leptospirosis is a life-threatening zoonotic disease and it has been hypothesized that the innate immune system fails to control the infection through ill-characterized mechanisms. The aim of this observational study was to better evaluate the activation processes of monocytes at the early stage of the disease. Blood samples were taken from healthy donors (n = 37) and patients hospitalized for either non-severe (n = 25) or severe (n = 32) leptospirosis. Monocyte cell counts and phenotypes were assessed by flow cytometry. We analysed the expression of several cell activation markers: CD14, CD16, HLA-DR, CD69, TLR2, TLR4, CD11b and CD11c. Although monocyte values at admittance were not significantly different from controls, patients experienced significant monocytosis at 1.33 × 10
Identifiants
pubmed: 30542761
doi: 10.1007/s00430-018-0575-9
pii: 10.1007/s00430-018-0575-9
doi:
Substances chimiques
Antigens, CD
0
Toll-Like Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-678Références
Infect Immun. 2002 Apr;70(4):1677-83
pubmed: 11895929
Shock. 2002 Apr;17(4):263-8
pubmed: 11954824
Scand J Immunol. 2002 Jun;55(6):629-38
pubmed: 12028567
Chest. 1992 Jun;101(6):1644-55
pubmed: 1303622
Lancet Infect Dis. 2003 Dec;3(12):757-71
pubmed: 14652202
Crit Care. 2004 Aug;8(4):R204-12
pubmed: 15312219
Immunol Lett. 2004 Sep;95(2):193-8
pubmed: 15388260
J Med Microbiol. 2005 Jan;54(Pt 1):45-9
pubmed: 15591254
Braz J Med Biol Res. 2005 Jun;38(6):909-14
pubmed: 15933785
J Immunol. 2005 Nov 1;175(9):6022-31
pubmed: 16237097
Shock. 2006 Apr;25(4):351-7
pubmed: 16670636
Intensive Care Med. 2006 Aug;32(8):1175-83
pubmed: 16741700
Asian Pac J Allergy Immunol. 2008 Dec;26(4):229-36
pubmed: 19317342
Ann Trop Med Parasitol. 2009 Jun;103(4):333-41
pubmed: 19508751
PLoS Negl Trop Dis. 2009 Jun 23;3(6):e463
pubmed: 19547748
Innate Immun. 2010 Apr;16(2):80-92
pubmed: 19587003
Crit Care. 2009;13(4):R119
pubmed: 19604380
Blood. 2010 Oct 21;116(16):e74-80
pubmed: 20628149
Intensive Care Med. 2010 Nov;36(11):1859-66
pubmed: 20652682
PLoS One. 2011 Mar 31;6(3):e18279
pubmed: 21483834
Cell Microbiol. 2011 Nov;13(11):1783-92
pubmed: 21819516
Mol Microbiol. 2012 Mar;83(5):1006-23
pubmed: 22329803
Immunol Res. 2012 Sep;53(1-3):41-57
pubmed: 22430559
Shock. 2012 Aug;38(3):227-42
pubmed: 22777111
PLoS Negl Trop Dis. 2013 Oct 10;7(10):e2477
pubmed: 24130911
Nat Rev Immunol. 2013 Dec;13(12):862-74
pubmed: 24232462
Int J Environ Res Public Health. 2014 Jan 10;11(1):968-82
pubmed: 24434593
Int Arch Med. 2014 Jun 21;7:31
pubmed: 25018781
J Microbiol Methods. 2014 Dec;107:205-13
pubmed: 25455022
Acta Anaesthesiol Scand. 2015 Aug;59(7):881-91
pubmed: 25866876
Sci Rep. 2015 Sep 11;5:13886
pubmed: 26358827
PLoS Negl Trop Dis. 2015 Sep 17;9(9):e0003898
pubmed: 26379143
PLoS Negl Trop Dis. 2016 May 11;10(5):e0004713
pubmed: 27167223
PLoS Negl Trop Dis. 2016 Jun 13;10(6):e0004733
pubmed: 27294677
PLoS One. 2016 Nov 1;11(11):e0165716
pubmed: 27802348
Front Immunol. 2017 Feb 21;8:58
pubmed: 28270811
BMC Microbiol. 2017 May 3;17(1):105
pubmed: 28468604
PLoS One. 2017 Jul 7;12(7):e0180474
pubmed: 28686648
PLoS One. 2017 Jul 11;12(7):e0181014
pubmed: 28700741
Curr Top Microbiol Immunol. 2018;415:163-187
pubmed: 29038956
Crit Care Med. 2018 Jan;46(1):93-99
pubmed: 29116996
Infect Immun. 1984 Dec;46(3):809-13
pubmed: 6500713
Blood. 1993 Nov 15;82(10):3170-6
pubmed: 7693040
FEMS Microbiol Lett. 1996 May 1;138(2-3):211-4
pubmed: 9026448