Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation.
Action-outcome
Frontostriatal
Goal-directed
Habit
Learning
Obsessive-compulsive disorder
Journal
Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
05
09
2018
accepted:
18
09
2018
pubmed:
14
12
2018
medline:
7
1
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
In obsessive-compulsive disorder (OCD), actions persist despite being inappropriate to the situation and without relationship to the overall goal. Dysfunctional beliefs have traditionally been postulated to underlie this condition. More recently, OCD has been characterized in terms of an imbalance between the goal-directed and the habit systems. To test these competing hypotheses, we used a novel experimental task designed to test subjective action-outcome knowledge of the effectiveness of actions (i.e., instrumental contingency), together with the balance between goal-directed and habitual responding. Twenty-seven patients with OCD and 27 healthy control subjects were tested on a novel task involving the degradation of an action-outcome contingency. Sensitivity to instrumental contingency and the extent to which explicitly reported action-outcome knowledge guided behavior were probed by measuring response rate and subjectively reported judgments. Patients with OCD responded more than healthy control subjects in situations in which an action was less causally related to obtaining an outcome. However, patients showed intact explicit action-outcome knowledge, as assessed by self-report. In patients, the relationship between causality judgment and responding was altered; therefore, their actions were dissociated from explicit action-outcome knowledge. These findings indicate reduced sensitivity to instrumental contingency in OCD, reinforcing the notion of a deficient goal-directed system in this disorder. By showing a dissociation between subjectively reported action-outcome knowledge and behavior, the data provide experimental evidence for the ego-dystonic nature of OCD.
Sections du résumé
BACKGROUND
In obsessive-compulsive disorder (OCD), actions persist despite being inappropriate to the situation and without relationship to the overall goal. Dysfunctional beliefs have traditionally been postulated to underlie this condition. More recently, OCD has been characterized in terms of an imbalance between the goal-directed and the habit systems. To test these competing hypotheses, we used a novel experimental task designed to test subjective action-outcome knowledge of the effectiveness of actions (i.e., instrumental contingency), together with the balance between goal-directed and habitual responding.
METHODS
Twenty-seven patients with OCD and 27 healthy control subjects were tested on a novel task involving the degradation of an action-outcome contingency. Sensitivity to instrumental contingency and the extent to which explicitly reported action-outcome knowledge guided behavior were probed by measuring response rate and subjectively reported judgments.
RESULTS
Patients with OCD responded more than healthy control subjects in situations in which an action was less causally related to obtaining an outcome. However, patients showed intact explicit action-outcome knowledge, as assessed by self-report. In patients, the relationship between causality judgment and responding was altered; therefore, their actions were dissociated from explicit action-outcome knowledge.
CONCLUSIONS
These findings indicate reduced sensitivity to instrumental contingency in OCD, reinforcing the notion of a deficient goal-directed system in this disorder. By showing a dissociation between subjectively reported action-outcome knowledge and behavior, the data provide experimental evidence for the ego-dystonic nature of OCD.
Identifiants
pubmed: 30545754
pii: S2451-9022(18)30253-2
doi: 10.1016/j.bpsc.2018.09.014
pmc: PMC6374986
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
200-209Subventions
Organisme : Medical Research Council
ID : G1000183
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104631/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M024873/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0001354
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009041/1
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.
Références
Philos Ethics Humanit Med. 2011 Feb 01;6:3
pubmed: 21284843
J Neurosci. 2011 Feb 16;31(7):2474-80
pubmed: 21325514
Transl Psychiatry. 2013 Dec 17;3:e337
pubmed: 24346135
Neuropharmacology. 1998 Apr-May;37(4-5):407-19
pubmed: 9704982
Behav Res Ther. 1985;23(5):571-83
pubmed: 4051930
Mem Cognit. 1991 Jul;19(4):353-60
pubmed: 1895945
J Exp Psychol Gen. 1979 Dec;108(4):441-85
pubmed: 528910
Psychiatr Clin North Am. 2000 Sep;23(3):563-86
pubmed: 10986728
Clin Psychol Rev. 2010 Jun;30(4):371-86
pubmed: 20189280
Neurosci Biobehav Rev. 2008;32(3):525-49
pubmed: 18061263
Behav Res Ther. 1993 May;31(4):423-5
pubmed: 8512543
Eur J Neurosci. 2005 Jul;22(2):505-12
pubmed: 16045503
Behav Res Ther. 1994 Mar;32(3):343-53
pubmed: 8192634
Philos Trans R Soc Lond B Biol Sci. 2014 Nov 5;369(1655):
pubmed: 25267818
J Neurosci. 2008 Jun 25;28(26):6750-5
pubmed: 18579749
Biol Psychiatry. 2017 Apr 15;81(8):708-717
pubmed: 27769568
J Anxiety Disord. 1998 Nov-Dec;12(6):525-37
pubmed: 9879033
Neuropsychopharmacology. 2014 May;39(6):1519-26
pubmed: 24385133
J Mem Lang. 2013 Apr;68(3):
pubmed: 24403724
Arch Gen Psychiatry. 1989 Nov;46(11):1006-11
pubmed: 2684084
Neuron. 2017 Oct 11;96(2):348-354.e4
pubmed: 28965997
Neurosci Biobehav Rev. 2014 Nov;47:281-94
pubmed: 25193245
Cereb Cortex. 2016 Jul;26(7):3273-84
pubmed: 27130662
Biol Psychiatry. 2013 Feb 15;73(4):321-8
pubmed: 23200527
Trends Cogn Sci. 2012 Jan;16(1):81-91
pubmed: 22155014
Am J Psychiatry. 2011 Jul;168(7):718-26
pubmed: 21572165
Behav Processes. 1989 Jun;19(1-3):167-80
pubmed: 24895910
J Exp Anal Behav. 1980 Nov;34(3):297-304
pubmed: 16812191
Eur J Neurosci. 2013 Aug;38(3):2382-8
pubmed: 23651226
Mol Psychiatry. 2015 Mar;20(3):345-52
pubmed: 24840709
Am J Psychiatry. 2015 Mar 1;172(3):284-93
pubmed: 25526600
Biol Psychiatry. 2014 Apr 15;75(8):631-8
pubmed: 23510580
J Exp Psychol Gen. 2018 Jul;147(7):1043-1065
pubmed: 29975092
J Clin Psychol. 1995 Nov;51(6):768-74
pubmed: 8778124
Neuron. 2004 Jan 22;41(2):281-92
pubmed: 14741108
J Abnorm Psychol. 2008 May;117(2):334-41
pubmed: 18489209
Nat Neurosci. 2005 Nov;8(11):1481-9
pubmed: 16251991
Behav Res Ther. 1986;24(2):133-43
pubmed: 3964179