Ginsenosides Act As Positive Modulators of P2X4 Receptors.

Adenosine Triphosphate / metabolism Animals Benzoxazoles / metabolism Calcium / metabolism Cell Death / drug effects Cell Line Ginsenosides / pharmacology HEK293 Cells Humans Ivermectin / pharmacology Mice Microglia / drug effects Quinolinium Compounds / metabolism Receptors, Purinergic P2X4 / metabolism Receptors, Purinergic P2X7 / metabolism Sapogenins / pharmacology

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
02 2019
Historique:
received: 23 07 2018
accepted: 10 12 2018
pubmed: 14 12 2018
medline: 15 6 2019
entrez: 15 12 2018
Statut: ppublish

Résumé

We investigated the selectivity of protopanaxadiol ginsenosides from

Identifiants

DOI: 10.1124/mol.118.113696 PMID: 30545933 PMC: PMC6334005
pubmed: 30545933
pii: mol.118.113696
doi: 10.1124/mol.118.113696
pmc: PMC6334005
doi:

Substances chimiques

Benzoxazoles 0
Ginsenosides 0
Quinolinium Compounds 0
Receptors, Purinergic P2X4 0
Receptors, Purinergic P2X7 0
Sapogenins 0
YO-PRO 1 152068-09-2
Ivermectin 70288-86-7
Adenosine Triphosphate 8L70Q75FXE
protopanaxadiol P6717R7BP8
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

210-221

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N018427/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P010660/1
Pays : United Kingdom

Informations de copyright

Copyright © 2019 The Author(s).

Références

Eur J Immunol. 2009 Apr;39(4):986-95
pubmed: 19283779
J Cell Sci. 2007 Nov 1;120(Pt 21):3838-49
pubmed: 17940064
Front Neurosci. 2014 Jun 24;8:176
pubmed: 25009459
Sci Rep. 2016 Aug 31;6:32461
pubmed: 27576299
Curr Med Chem. 2017;24(21):2261-2275
pubmed: 28266268
Circ Res. 2000 Sep 1;87(5):385-91
pubmed: 10969036
Nat Neurosci. 1999 Apr;2(4):322-30
pubmed: 10204538
J Neurochem. 2016 Oct;139(1):134-48
pubmed: 27402173
Front Cell Neurosci. 2013 Oct 08;7:171
pubmed: 24115920
Bioinformatics. 2007 Nov 1;23(21):2947-8
pubmed: 17846036
J Gen Physiol. 2004 Mar;123(3):281-93
pubmed: 14769846
J Ginseng Res. 2013 Oct;37(4):451-6
pubmed: 24235859
Neuropharmacology. 2018 Jan;128:11-21
pubmed: 28943285
Nature. 2012 May 10;485(7397):207-12
pubmed: 22535247
Front Mol Neurosci. 2016 Oct 28;9:111
pubmed: 27840602
Rev Neurosci. 2011;22(3):335-54
pubmed: 21639805
Nature. 2003 Aug 14;424(6950):778-83
pubmed: 12917686
Mol Pharmacol. 2015 Apr;87(4):606-16
pubmed: 25597706
J Neurosci. 2006 Aug 30;26(35):9006-9
pubmed: 16943557
J Med Chem. 2006 Jan 26;49(2):534-53
pubmed: 16420040
Nat Med. 2006 Jan;12(1):133-7
pubmed: 16327800
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Neuropharmacology. 2010 Mar;58(3):569-77
pubmed: 20004677
Glia. 2012 May;60(5):728-37
pubmed: 22318986
Chem Biol Drug Des. 2007 Feb;69(2):146-8
pubmed: 17381729
Cell Physiol Biochem. 2013;32(1):11-24
pubmed: 23867750
Alcohol Clin Exp Res. 2015 Oct;39(10):2022-31
pubmed: 26334550
Front Pharmacol. 2017 May 23;8:291
pubmed: 28588493
Br J Pharmacol. 2015 Jul;172(13):3326-40
pubmed: 25752193
Physiol Rev. 2002 Oct;82(4):1013-67
pubmed: 12270951
Nature. 2005 Dec 15;438(7070):1017-21
pubmed: 16355225
Neuropharmacology. 2012 Aug;63(2):190-201
pubmed: 22465817
Pharmacol Rev. 2011 Sep;63(3):641-83
pubmed: 21737531
Neuron. 2007 Apr 19;54(2):263-74
pubmed: 17442247
J Neurosci. 2008 Oct 29;28(44):11263-8
pubmed: 18971468
J Neurosci. 1999 Sep 1;19(17):7289-99
pubmed: 10460235
Exp Gerontol. 2014 Feb;50:95-105
pubmed: 24316034
Biochem Biophys Res Commun. 1996 Jun 14;223(2):456-60
pubmed: 8670303
Br J Pharmacol. 2003 Oct;140(3):567-75
pubmed: 12970084
J Immunol. 2018 Feb 1;200(3):1159-1168
pubmed: 29255078
Alcohol Clin Exp Res. 2011 Apr;35(4):584-94
pubmed: 21223299
J Biol Chem. 2011 Apr 1;286(13):11067-81
pubmed: 21262970
EMBO J. 2010 Jul 21;29(14):2290-300
pubmed: 20562826
Mol Cells. 2013 Feb;35(2):142-50
pubmed: 23456336
Front Physiol. 2014 Mar 19;5:98
pubmed: 24678300
J Med Chem. 2012 Nov 26;55(22):9576-88
pubmed: 23075067
Neuropharmacology. 1998 Dec;37(12):1579-86
pubmed: 9886680
Pharmacol Rev. 2014 Jul;66(3):638-75
pubmed: 24928329
Br J Pharmacol. 2012 Sep;167(1):48-66
pubmed: 22506590
Eur J Pharmacol. 1998 Aug 21;355(2-3):235-44
pubmed: 9760038
Purinergic Signal. 2013 Dec;9(4):621-32
pubmed: 23817978
Biochem Biophys Res Commun. 2006 Oct 20;349(2):619-25
pubmed: 16949036
Nat Neurosci. 1999 Apr;2(4):315-21
pubmed: 10204537
Front Pharmacol. 2018 Jan 11;8:965
pubmed: 29375375
Chin J Nat Med. 2018 Mar;16(3):175-183
pubmed: 29576053
J Pharmacol Exp Ther. 2010 Sep 1;334(3):720-8
pubmed: 20543096

Auteurs

Kshitija Dhuna (K)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Matthew Felgate (M)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Stefan M Bidula (SM)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Samuel Walpole (S)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Lucka Bibic (L)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Brett A Cromer (BA)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Jesus Angulo (J)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Julie Sanderson (J)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Martin J Stebbing (MJ)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.).

Leanne Stokes (L)

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia (K.D., B.A.C., M.J.S., L.S.); School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom (M.F., S.M.B., S.W., L.B., J.A., J.S., L.S.); Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia (B.A.C.); and Florey Institute of Neuroscience and Mental Health, Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia (M.J.S.) l.stokes@uea.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Eucaryotes › Animaux › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzoxazoles › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Glucides › Hétérosides › Saponines › Ginsénosides › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Ivermectine › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinoléinium, composés › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2X › Récepteurs purinergiques P2X4 › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2X › Récepteurs purinergiques P2X7 › Ginsenosides Act As Positive Modulators of...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sapogénines › Ginsenosides Act As Positive Modulators of...