Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells.
Anemia
/ genetics
Autophagy
/ genetics
Autophagy-Related Protein 5
/ genetics
Autophagy-Related Protein-1 Homolog
/ genetics
Cell Differentiation
/ drug effects
Ceramides
/ genetics
Erythropoiesis
/ genetics
Gene Expression Regulation, Developmental
/ genetics
Hematopoietic Stem Cells
/ metabolism
Humans
Inflammation
/ genetics
Myelopoiesis
/ genetics
Neoplasms
/ genetics
Phosphorylation
/ drug effects
Signal Transduction
/ genetics
Sphingolipids
/ genetics
Sphingomyelin Phosphodiesterase
/ genetics
TOR Serine-Threonine Kinases
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
15
08
2017
accepted:
19
11
2018
revised:
04
11
2018
pubmed:
14
12
2018
medline:
1
9
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptosis, senescence, and autophagy. Here we evaluated the implication of the TNFα/SMase/ceramide pathway on inhibition of erythropoiesis in human CD34
Identifiants
pubmed: 30546074
doi: 10.1038/s41418-018-0245-x
pii: 10.1038/s41418-018-0245-x
pmc: PMC6748125
doi:
Substances chimiques
Autophagy-Related Protein 5
0
Ceramides
0
Sphingolipids
0
Tumor Necrosis Factor-alpha
0
MTOR protein, human
EC 2.7.1.1
Autophagy-Related Protein-1 Homolog
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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