Fusobacterium nucleatum - symbiont, opportunist and oncobacterium.
Journal
Nature reviews. Microbiology
ISSN: 1740-1534
Titre abrégé: Nat Rev Microbiol
Pays: England
ID NLM: 101190261
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
14
12
2018
medline:
7
1
2020
entrez:
15
12
2018
Statut:
ppublish
Résumé
Fusobacterium nucleatum has long been found to cause opportunistic infections and has recently been implicated in colorectal cancer; however, it is a common member of the oral microbiota and can have a symbiotic relationship with its hosts. To address this dissonance, we explore the diversity and niches of fusobacteria and reconsider historic fusobacterial taxonomy in the context of current technology. We also undertake a critical reappraisal of fusobacteria with a focus on F. nucleatum as a mutualist, infectious agent and oncogenic microorganism. In this Review, we delve into recent insights and future directions for fusobacterial research, including the current genetic toolkit, our evolving understanding of its mechanistic role in promoting colorectal cancer and the challenges of developing diagnostics and therapeutics for F. nucleatum.
Identifiants
pubmed: 30546113
doi: 10.1038/s41579-018-0129-6
pii: 10.1038/s41579-018-0129-6
pmc: PMC6589823
mid: NIHMS1033346
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
156-166Subventions
Organisme : NCI NIH HHS
ID : R01 CA154426
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA207021
Pays : United States
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