Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production.

A549 Cells Adenosine Triphosphate / metabolism Antineoplastic Agents, Phytogenic / pharmacology Benzylisoquinolines / pharmacology Cell Survival / drug effects Humans Mitochondria / drug effects Reactive Oxygen Species / metabolism
A549 ATP depletion Glycolysis Mitochondria Tetrandrine

Journal

Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264

Informations de publication

Date de publication:
04 2019
Historique:
received: 05 09 2018
accepted: 06 12 2018
pubmed: 14 12 2018
medline: 25 4 2020
entrez: 15 12 2018
Statut: ppublish

Résumé

ATP depletion induced by inhibiting glycolysis or mitochondrial ATP production has been demonstrated to cause cancer cell death. Whether ATP depletion can enhance the efficacy and potency of anti-cancer effects of herbal compounds is so far unknown. We examined the enhancing effect of ATP depletion on anti-cancer actions of tetrandrine (TET) in human lung carcinoma A549 cells. A 24-h incubation of A549 cells with tetrandrine caused a concentration-dependent cytotoxic effect (LC

Identifiants

DOI: 10.1007/s00210-018-01601-2 PMID: 30547225
pubmed: 30547225
doi: 10.1007/s00210-018-01601-2
pii: 10.1007/s00210-018-01601-2
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Benzylisoquinolines 0
Reactive Oxygen Species 0
tetrandrine 29EX23D5AJ
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

427-436

Références

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Auteurs

Louis W C Chow (LWC)

State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
UNIMED Medical Institute and Organisation for Oncology and Translational Research, Hong Kong, China.
Organisation for Oncology and Translational Research, Hong Kong, China.

Ka-Shun Cheng (KS)

Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.

Fai Leong (F)

Department of Anaesthesiology of Centro Hospitalar conde de Sao Januario, Macao Health Bureau, Macau, SAR, China.

Chi-Wai Cheung (CW)

Laboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Lian-Ru Shiao (LR)

Department of Physiology, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan, Republic of China.

Yuk-Man Leung (YM)

Department of Physiology, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan, Republic of China. ymleung@mail.cmu.edu.tw.
ORCID: 0000-0002-0626-1768

Kar-Lok Wong (KL)

Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan. klwong@mail.cmuh.org.tw.
Laboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. klwong@mail.cmuh.org.tw.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Benzylisoquinoléines › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Enhancing tetrandrine cytotoxicity in human...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Enhancing tetrandrine cytotoxicity in human...