Toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 cell line.
Animals
Apoptosis
/ drug effects
Cell Culture Techniques
Cell Line
Cell Survival
/ drug effects
Cerium
/ chemistry
Copper
/ chemistry
DNA Damage
Dose-Response Relationship, Drug
Embryo, Nonmammalian
/ drug effects
Humans
Nanoparticles
/ chemistry
Surface Properties
Water Pollutants, Chemical
/ chemistry
Zebrafish
/ embryology
apoptosis
genotoxicity
nanotoxicology
Journal
Environmental toxicology
ISSN: 1522-7278
Titre abrégé: Environ Toxicol
Pays: United States
ID NLM: 100885357
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
30
07
2018
revised:
19
11
2018
accepted:
24
11
2018
pubmed:
15
12
2018
medline:
23
4
2019
entrez:
15
12
2018
Statut:
ppublish
Résumé
Metal and metal oxide nanoparticles are being used in different industries now-a-days leading to their unavoidable exposure to humans and animals. In the present study, toxicological testing was done using nanoparticles of copper oxide, cerium oxide and their mixture (1:1 ratio) on zebra fish embryos and THP-1 cell line. Zebrafish embryos were exposed to 0.01 μg/ml to 50 μg/ml concentrations of dispersed nanoparticles using a 96 well plate and their effects were studied at different hours post fertilization (hpf) i.e. 0 hpf, 24 hpf, 48 hpf, 72 hpf and 96 hpf respectively. Results showed that copper oxide nanoparticles has drastic effects on the morphology and physiology of zebra fish whereas cerium oxide nanoparticles and mixture of these nanoparticles did not show much of the effects. Comparable results were obtained from in vitro study using human monocyte cell line (THP-1). It is concluded that these nanoparticles may cause toxicological effects to humans and environment.
Identifiants
pubmed: 30548797
doi: 10.1002/tox.22692
pmc: PMC6492081
doi:
Substances chimiques
Water Pollutants, Chemical
0
Cerium
30K4522N6T
ceric oxide
619G5K328Y
Copper
789U1901C5
cuprous oxide
T8BEA5064F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
375-387Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/E/14/1/501777
Pays : India
Informations de copyright
© 2018 The Authors. Environmental Toxicology published by Wiley Periodicals, Inc.
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